Ensuring the proper amount of water inside the body is essential for survival. One of the key
factors in the maintenance of body water balance is water reabsorption in the collecting …

Multiple myeloma (MM) is a common malignant tumor of plasma cells. Despite several
treatment approaches in the past two decades, MM remains an aggressive and incurable …

Multiplexed profiling of microRNAs' subcellular expression and distribution is essential to
understand their spatiotemporal function information, but it remains a crucial challenge …

Objectives To explore the mechanism of calcium-sensing receptors (CaSRs) during the
development of nephrolithiasis. Materials and methods Wistar rats were treated with …

The calcium-sensing receptor (CaSR) is the main regulator of extracellular Ca2+
homeostasis. It has diverse functions in different tissues, including the intestines. Intestine …

Vasopressin (AVP) increases water permeability in the renal collecting duct through the
regulation of aquaporin-2 (AQP2) trafficking. Several disorders, including hypertension and …

High concentrations of urinary calcium counteract vasopressin action via the activation of the
Calcium‐Sensing Receptor (CaSR) expressed in the luminal membrane of the collecting …

Idiopathic osteoporosis and nephrolithiasis are formidable health problems showing a
progressive increase in their incidence and prevalence in the last decades. These temporal …

Background The combined effects of glyphosate and hard water on chronic kidney disease
of unknown etiology (CDKu) have attracted much interest, but the mechanisms remain …

The study of transient receptor potential (TRP) channels has dramatically increased during
the past few years. TRP channels function as sensors and effectors in the cellular adaptation …