Inorganic phosphate (Pi) plays a critical function in many tissues of the body: for example, as
part of the hydroxyapatite in the skeleton and as a substrate for ATP synthesis. Pi is the main …

Over the past 25 years, successive cloning of SLC34A1, SLC34A2 and SLC34A3, which
encode the sodium-dependent inorganic phosphate (Pi) cotransport proteins 2a–2c, has …

Sodium (Na+) is the principal osmole in extracellular fluid; as such, the total body content of
Na+ and Cl-, its primary anion, determine the extracellular fluid volume. Renal excretion or …

Renal proximal tubular reabsorption of Pi is a key element in overall Pi homeostasis, and it
involves a secondary active Pi transport mechanism. Among the molecularly identified …

Transport of inorganic phosphate (Pi) across the plasma membrane is essential for normal
cellular function. Members of two families of SLC proteins (SLC20 and SLC34) act as Na+ …

This review summarizes the characteristics of the solute carrier family SLC34 that is
represented by the type ll Na/P i-cotransporters NaPi-lla (SLC34A1), NaPi-llb (SLC34A2) …

Phosphate is an essential component of life and must be actively transported into cells
against its electrochemical gradient. In vertebrates, two unrelated families of Na+-dependent …

Members of the SLC34 gene family of solute carriers encode for three Na+-dependent
phosphate (P i) cotransporter proteins, two of which (NaPi-IIa/SLC34A1 and NaPi …

Plasma phosphate concentration is maintained within a relatively narrow range by control of
renal reabsorption of filtered inorganic phosphate (Pi). Pi reabsorption is a transcellular …

The SLC34 family of sodium-driven phosphate cotransporters comprises three members:
NaPi-IIa (SLC34A1), NaPi-IIb (SLC34A2), and NaPi-IIc (SLC34A3). These transporters …