Tumor microenvironment (TME) takes critical roles in tumor resistance to immune checkpoint
inhibitors (ICIs) including anti-programmed death-1 (PD-1) or anti-programmed death-ligand …

Metabolic alterations occur commonly in tumor cells as a way to adapt available energetic
sources for their proliferation, survival and resistance. Indoleamine 2, 3-dioxygenase 1 …

Microphthalmia transcription factor (MiT) family translocation renal cell carcinoma (tRCC) is
a rare type of kidney cancer, which is not well characterized. Here we show the …

The ecosystem of brain tumors is considered immunosuppressed, but our current
knowledge may be incomplete. Here we analyzed clinical cell and tissue specimens derived …

Immune evasion is indispensable for cancer initiation and progression, although its
underlying mechanisms in pancreatic ductal adenocarcinoma (PDAC) are not fully known …

Background Several models and algorithms have been proposed to build pangenomes from
multiple input assemblies, but their impact on variant representation, and consequently …

Glioblastoma multiforme is a highly malignant brain tumor with significant intra-and
intertumoral heterogeneity known for its aggressive nature and poor prognosis. The complex …

In recent years, several studies described the close relationship between the composition of
gut microbiota and brain functions, highlighting the importance of gut-derived metabolites in …

Single-cell RNA sequencing can reveal valuable insights into cellular heterogeneity within
tumour microenvironments (TMEs), paving the way for a deep understanding of cellular …

Low frequency of durable responses in patients treated with immune checkpoint inhibitors
(ICIs) demands for taking complementary strategies in order to boost immune responses …