Fatty acid metabolism is known to support tumorigenesis and disease progression as well
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …

Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …

The physiological function of the epidermal growth factor receptor (EGFR) is to regulate
epithelial tissue development and homeostasis. In pathological settings, mostly in lung and …

Over the past decade, the study of metabolic abnormalities in cancer cells has risen
dramatically. Cancer cells can thrive in challenging environments, be it the hypoxic and …

A distinctive feature of cancer cells of various origins involves alterations of the composition
of lipids, with significant enrichment in monounsaturated fatty acids. These molecules, in …

Cancer cells are characterized by metabolic alterations. Thereinto, Stearoyl-CoA
Desaturase 1 (SCD1), an enzymatic node located in the conversion of saturated fatty acids …

Chemotherapy is one of the primary treatments for most human cancers. Despite great
progress in cancer therapeutics, chemotherapy continues to be important for improving the …

Abstract The Epidermal Growth Factor Receptor (EGFR) is frequently expressed at elevated
levels in different forms of cancer and expression often correlates positively with cancer …

Lung cancer is the leading cause of cancer deaths worldwide. Most of lung cancer cases are
classified as non-small cell lung cancers (NSCLC). EGFR has become an important …

The constant changes in cancer cell bioenergetics are widely known as metabolic
reprogramming. Reprogramming is a process mediated by multiple factors, including …