Abstract Point-of-care (POC) device development is a growing field that aims to develop low-
cost, rapid, sensitive in-vitro diagnostic testing platforms that are portable, self-contained …

Conjugation of aptamers and their corresponding analytes onto plasmonic nanoparticles
mediates the formation of nanoparticle assemblies: molecularly bound nanoclusters that …

表面增强拉曼光谱(SERS) 是一种超灵敏的生化分析技术ꎬ 已经被广泛运用于细胞, 核酸,
蛋白质等生物分子的检测ꎬ 在生物医学领域表现出了巨大的应用潜力ꎮ 近年来ꎬ …

With an ageing population1 we are seeing a rise in many age-related diseases which are
having long-term health implications for patients and cost implications for our health …

Interferometric measurements of free solution assays (FSAs) quantify changes in molecular
conformation and hydration upon binding. Here, we demonstrate that aptamer probes …

The work in this thesis focuses on improving the understanding of two key aspects of the
interaction between dye molecules and metallic nanoparticles, with particular relevance to …