[HTML][HTML] Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments
R Ruze, T Liu, X Zou, J Song, Y Chen, R Xu… - Frontiers in …, 2023 - frontiersin.org
The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …
[HTML][HTML] Metabolism of amino acids in cancer
Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The
uptake and metabolism of amino acids are aberrantly upregulated in many cancers that …
uptake and metabolism of amino acids are aberrantly upregulated in many cancers that …
[HTML][HTML] Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 …
F Vanweert, P Schrauwen, E Phielix - Nutrition & diabetes, 2022 - nature.com
Branched-chain amino acid (BCAA) catabolism has been considered to have an emerging
role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D) …
role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D) …
[HTML][HTML] Insulin action, type 2 diabetes, and branched-chain amino acids: a two-way street
Background A strong association of obesity and insulin resistance with increased circulating
levels of branched-chain and aromatic amino acids and decreased glycine levels has been …
levels of branched-chain and aromatic amino acids and decreased glycine levels has been …
Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
SE Arnold, Z Arvanitakis… - Nature Reviews …, 2018 - nature.com
Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …
[HTML][HTML] Emerging roles for branched-chain amino acid metabolism in cancer
S Sivanand, MG Vander Heiden - Cancer cell, 2020 - cell.com
Metabolic pathways must be adapted to support cell processes required for transformation
and cancer progression. Amino acid metabolism is deregulated in many cancers, with …
and cancer progression. Amino acid metabolism is deregulated in many cancers, with …
Metabolites as regulators of insulin sensitivity and metabolism
Q Yang, A Vijayakumar, BB Kahn - Nature reviews Molecular cell …, 2018 - nature.com
The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …
Human gut microbes impact host serum metabolome and insulin sensitivity
Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2
diabetes. Here we show how the human gut microbiome impacts the serum metabolome …
diabetes. Here we show how the human gut microbiome impacts the serum metabolome …
[HTML][HTML] Quantitative analysis of the whole-body metabolic fate of branched-chain amino acids
Elevations in branched-chain amino acids (BCAAs) associate with numerous systemic
diseases, including cancer, diabetes, and heart failure. However, an integrated …
diseases, including cancer, diabetes, and heart failure. However, an integrated …
Brain insulin signalling in metabolic homeostasis and disease
T Scherer, K Sakamoto, C Buettner - Nature Reviews Endocrinology, 2021 - nature.com
Insulin signalling in the central nervous system regulates energy homeostasis by controlling
metabolism in several organs and by coordinating organ crosstalk. Studies performed in …
metabolism in several organs and by coordinating organ crosstalk. Studies performed in …