Abstract Type 2 diabetes (T2DM) is characterized by insulin resistance, defective insulin
secretion, loss of β-cell mass with increased β-cell apoptosis and islet amyloid. The islet …

Layer-by-layer (LbL) was first introduced as a surface modification technique based on the
sequential spontaneous adsorption of at least two distinct materials onto planar substrates …

Islet transplantation is a promising alternative therapy for insulin-dependent patients, with
the potential to eliminate life-threatening hypoglycemic episodes and secondary …

Angiopoietins 1 and 2 bind to Tie-2 expressed on endothelial cells and regulate vessel
stabilization and angiogenesis. Tie-2+ monocytes have been shown to be recruited to …

Novel transplantation techniques are currently under development to preserve the function
of impaired tissues or organs. While current technologies can enhance the survival of …

Layer-by-layer assembly of polyelectrolyte multilayer (PEM) films represents a bottom-up
approach for re-engineering the molecular landscape of cell surfaces with spatially …

Protection of transplanted cells from the host immune system using immunoisolation
technology will be important in realizing the full potential of cell-based therapeutics …

Type 1 diabetes is associated with a progressive loss of β cells and pancreatic islet
transplantation could represent a cure for this disease. Herein we explored whether …

Biofunctionalized polyethylene glycol maleimide (PEG–MAL) hydrogels were engineered as
a platform to deliver pancreatic islets to the small bowel mesentery and promote graft …

Background Inadequate extracellular conditions can adversely affect the environment of the
ER and impinge on the maturation of nascent proteins. The resultant accumulation of …