Phenotypic approaches to obstructive sleep apnoea–new pathways for targeted therapy

DJ Eckert - Sleep medicine reviews, 2018 - Elsevier
People develop obstructive sleep apnoea (OSA) for different reasons. The ability to
understand these reasons, easily identify them in individual patients, and develop therapies …

Obstructive sleep apnea and inflammation: proof of concept based on two illustrative cytokines

L Kheirandish-Gozal, D Gozal - International journal of molecular …, 2019 - mdpi.com
Obstructive sleep apnea syndrome (OSAS) is a markedly prevalent condition across the
lifespan, particularly in overweight and obese individuals, which has been associated with …

Adult obstructive sleep apnoea

AS Jordan, DG McSharry, A Malhotra - The Lancet, 2014 - thelancet.com
Obstructive sleep apnoea is an increasingly common disorder of repeated upper airway
collapse during sleep, leading to oxygen desaturation and disrupted sleep. Features include …

A method for measuring and modeling the physiological traits causing obstructive sleep apnea

A Wellman, DJ Eckert, AS Jordan… - Journal of applied …, 2011 - journals.physiology.org
There is not a clinically available technique for measuring the physiological traits causing
obstructive sleep apnea (OSA). Therefore, it is often difficult to determine why an individual …

A simplified method for determining phenotypic traits in patients with obstructive sleep apnea

A Wellman, BA Edwards, SA Sands… - Journal of applied …, 2013 - journals.physiology.org
We previously published a method for measuring several physiological traits causing
obstructive sleep apnea (OSA). The method, however, had a relatively low success rate …

Upper airway collapsibility (Pcrit) and pharyngeal dilator muscle activity are sleep stage dependent

JC Carberry, AS Jordan, DP White, A Wellman… - Sleep, 2016 - academic.oup.com
Abstract Study Objectives: An anatomically narrow/highly collapsible upper airway is the
main cause of obstructive sleep apnea (OSA). Upper airway muscle activity contributes to …

Anatomical determinants of upper airway collapsibility in obstructive sleep apnea: a systematic review and meta-analysis

PJ Hartfield, J Janczy, A Sharma, HA Newsome… - Sleep Medicine …, 2023 - Elsevier
Upper airway (UA) collapsibility is one of the key factors that determine the severity of
obstructive sleep apnea (OSA). Interventions for OSA are aimed at reducing UA …

Upper airway collapsibility is associated with obesity and hyoid position

PR Genta, F Schorr, DJ Eckert, E Gebrim, F Kayamori… - Sleep, 2014 - academic.oup.com
Abstract Study Objectives: Upper airway anatomy plays a major role in obstructive sleep
apnea (OSA) pathogenesis. An inferiorly displaced hyoid as measured by the mandibular …

[HTML][HTML] Mechanical properties of the upper airway

KP Strohl, JP Butler, A Malhotra - Comprehensive Physiology, 2012 - ncbi.nlm.nih.gov
The importance of the upper airway (nose, pharynx, and larynx) in health and in the
pathogenesis of sleep apnea, asthma, and other airway diseases, discussed elsewhere in …

Obstructive sleep apnea

DP White, MK Younes - Comprehensive Physiology, 2012 - Wiley Online Library
Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive collapse of
the pharyngeal airway during sleep. Control of pharyngeal patency is a complex process …