[HTML][HTML] Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies

SV Bhujbal, B Mitra, U Jain, Y Gong, A Agrawal… - … Pharmaceutica Sinica B, 2021 - Elsevier
Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and
bioavailability of poorly water-soluble drugs. Various approaches have been employed to …

Amorphous solid dispersions: An update for preparation, characterization, mechanism on bioavailability, stability, regulatory considerations and marketed products

P Pandi, R Bulusu, N Kommineni, W Khan… - International journal of …, 2020 - Elsevier
Amorphous solid dispersions (ASDs) are being employed frequently to improve
bioavailability of poorly soluble molecules by enhancing the rate and extant of dissolution in …

Mechanisms of increased bioavailability through amorphous solid dispersions: a review

A Schittny, J Huwyler, M Puchkov - Drug Delivery, 2020 - Taylor & Francis
Amorphous solid dispersions (ASDs) can increase the oral bioavailability of poorly soluble
drugs. However, their use in drug development is comparably rare due to a lack of basic …

50 years of oral lipid-based formulations: provenance, progress and future perspectives

OM Feeney, MF Crum, CL McEvoy, NL Trevaskis… - Advanced drug delivery …, 2016 - Elsevier
Lipid based formulations (LBF) provide well proven opportunities to enhance the oral
absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of …

Physical chemistry of supersaturated solutions and implications for oral absorption

LS Taylor, GGZ Zhang - Advanced drug delivery reviews, 2016 - Elsevier
Amorphous solid dispersion (ASD) formulations are widely used for delivery of poorly
soluble drugs for dissolution enhancement and bioavailability improvement. When …

[HTML][HTML] Advances in the development of amorphous solid dispersions: The role of polymeric carriers

J Zhang, M Guo, M Luo, T Cai - Asian Journal of Pharmaceutical Sciences, 2023 - Elsevier
Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …

Systematic screening of pharmaceutical polymers for hot melt extrusion processing: A comprehensive review

R Thakkar, R Thakkar, A Pillai, EA Ashour… - International journal of …, 2020 - Elsevier
Pharmaceutical research, whether industrial or academic, has attempted to adopt
approaches most efficient for the development of innovations. With the abundance of …

Recent advances in cellulose, pectin, carrageenan and alginate-based oral drug delivery systems

N Raghav, C Vashisth, N Mor, P Arya… - International Journal of …, 2023 - Elsevier
Polymers-based drug delivery systems constitute one of the highly explored thrust areas in
the field of the medicinal and pharmaceutical industries. In the past years, the properties of …

Evaluation of gastrointestinal drug supersaturation and precipitation: strategies and issues

J Bevernage, J Brouwers, ME Brewster… - International journal of …, 2013 - Elsevier
Supersaturating drug delivery systems (SDDS) hold the promise of enabling intestinal
absorption for difficult-to-formulate, poorly soluble drug candidates based on a design …

Improving drug design: an update on recent applications of efficiency metrics, strategies for replacing problematic elements, and compounds in nontraditional drug …

NA Meanwell - Chemical Research in Toxicology, 2016 - ACS Publications
Drug discovery and development is a complex and lengthy enterprise that suffers from high
rates of candidate attrition at all stages of the process. The physical, biological, and …