Gastrointestinal diseases including diarrhoea constitute a major cause of morbidity and
mortality in infants and young children especially in developing countries. Worldwide deaths …

Rotavirus is a major cause of severe acute gastroenteritis in the infants and young children.
The past decade has evidenced the role of intrinsically disordered proteins/regions …

Rotavirus vaccines are well tolerated and provide adequate protection against moderate to
severe disease in high, middle and low-income regions. Partnerships between …

Although significant clinical efficacy and safety of rotavirus vaccines were recently revealed
in many countries, the mechanism of their attenuation is not well understood. We passaged …

Diarrheal disease continues to be a major cause of global morbidity and mortality among
children under 5 years of age. To address the current issues associated with oral attenuated …

ABSTRACT A novel pentameric structure which differs from the previously reported
tetrameric form of the diarrhea-inducing region of the rotavirus enterotoxin NSP4 is reported …

Rotavirus (RV)-infected piglets are presumed to be latent sources of heterologous RV
infection in humans and other animals. In RVs, non-structural protein 4 (NSP4) is the major …

Group A rotaviruses (RVA) are the leading cause of acute gastroenteritis (AGE) in young
children worldwide. The RVA outer capsid layer is composed of the VP7 and VP4 proteins …

Rotavirus nonstructural protein 4, the first viral enterotoxin to be identified, is a multidomain,
multifunctional glycoprotein. Earlier, we reported a Ca 2+-bound coiled-coil tetrameric …

Rotavirus was first identified as a human pathogen just over 40 years ago, and work on this
pathogen in India started shortly thereafter. Subsequent studies have confirmed its pre …