Although initially described as an anti-tumor mediator, tumor necrosis factor-alpha (TNF) is
generally considered as the master pro-inflammatory cytokine. It plays a crucial role in the …

Tumor necrosis factor (TNF) is a central regulator of immunity. Due to its dominant pro-
inflammatory effects, drugs that neutralize TNF were developed and are clinically used to …

Alpha-synuclein (αS) is causally involved in the development of Parkinson disease (PD);
however, its role in normal vertebrate physiology has remained unknown. Recent studies …

Immune checkpoint inhibitors (ICIs) are effective in the treatment of patients with advanced
cancer and have emerged as a pillar of standard cancer care. However, their use is …

Treatments that block tumour necrosis factor (TNF) have major beneficial effects in several
autoimmune and rheumatic diseases, including rheumatoid arthritis. However, some …

Costimulatory signals initiated by the interaction between the tumor necrosis factor (TNF)
ligand and cognate TNF receptor (TNFR) superfamilies promote clonal expansion …

CD4+ T cells turn pathological during heart failure (HF). We show that the expression of
tumor necrosis factor (TNF)-α and tumor necrosis factor receptor (TNFR1) increases in HF …

TNF, produced largely by T and innate immune cells, is potently proinflammatory, as are
cytokines such as IFN-γ and IL-17 produced by Th1 and Th17 cells, respectively. Here, we …

Cytokines are critical in regulating immune responses and cellular behavior, playing dual
roles in both normal physiology and the pathology of diseases such as cancer. These …

TNF is a key proinflammatory and immunoregulatory cytokine whose deregulation is
associated with the development of autoimmune diseases and other pathologies. Recent …