Proteins span an extraordinary range of shapes, sizes and functionalities. Therefore generic
approaches are needed to overcome this diversity and stream-line protein analysis or …

Clonal selection theory proposed that individual T cells are specific for a single peptide–
MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast …

T cells respond to threats in an antigen-specific manner using T cell receptors (TCRs) that
recognize short peptide antigens presented on major histocompatibility complex (MHC) …

We studied the prevalent cytotoxic CD8 T cell response mounted against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike glycoprotein 269-277 epitope …

Background & Aims Ligand binding to inhibitory receptors on immune cells, such as
programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 (CTLA4) …

Protein therapeutics hold a prominent and rapidly expanding place among medicinal
products. Purified blood products, recombinant cytokines, growth factors, enzyme …

Peptide-MHC (pMHC) multimers have excelled in the detection of antigen-specific T cells
and have allowed phenotypic analysis using other reagents, but their use for detection of …

T cell activation is a crucial checkpoint in adaptive immunity, and this activation depends on
the binding parameters that govern the interactions between T cell receptors (TCRs) and …

Autologous T cells transduced to express a high affinity T-cell receptor specific to NY-ESO-1
(letetresgene autoleucel, lete-cel) show promise in the treatment of metastatic synovial …

Mucosal-associated invariant T (MAIT) cells detect microbial infection via recognition of
riboflavin-based antigens presented by the major histocompatibility complex class I (MHC-I) …