Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion diseases are …

Polyglutamine (polyQ) sequences of unknown normal function are present in a significant
number of proteins, and their repeat expansion is associated with a number of genetic …

A long-standing goal of amyloid research has been to characterize the structural basis of the
rate-determining nucleating event. However, the ephemeral nature of nucleation has made …

At least nine dominant neurodegenerative diseases are caused by expansion of CAG
repeats in coding regions of specific genes that result in abnormal elongation of …

The history of polyglutamine diseases dates back approximately 20 years to the discovery of
a polyglutamine repeat in the androgen receptor of SBMA followed by the identification of …

Abstract Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative
disorder that primarily affects the cerebellum and brainstem. The genetic mutation is an …

Huntington disease is an autosomal-dominant neurodegenerative disorder caused by a
polyglutamine (polyQ) expansion (> 35Q) in the first exon (EX1) of huntingtin protein (Htt) …

Polyglutamine (polyQ) diseases, including Huntington's disease, result from the aggregation
of an abnormally expanded polyQ repeat in the affected protein. The length of the polyQ …

Abnormally expanded polyglutamine (polyQ) tracts provide a gain of toxic functions to nine
otherwise unrelated human proteins and induce progressive neurodegenerative diseases …

The family of hereditary cerebellar ataxias is a large group of disorders with heterogenous
clinical manifestations and genetic etiologies. Among these, over 30 autosomal dominantly …