Bystander T cells in cancer immunology and therapy

SL Meier, AT Satpathy, DK Wells - Nature Cancer, 2022 - nature.com
Cancer-specific T cells are required for effective anti-cancer immunity and have a central
role in cancer immunotherapy. However, emerging evidence suggests that only a small …

The evolving role of tissue-resident memory T cells in infections and cancer

S Yenyuwadee, JL Sanchez-Trincado Lopez… - Science …, 2022 - science.org
Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in
tissues. TRM form an integral part of the immune sensing network and have the ability to …

Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis

A Barmada, J Klein, A Ramaswamy, NN Brodsky… - Science …, 2023 - science.org
Rare immune-mediated cardiac tissue inflammation can occur after vaccination, including
after SARS-CoV-2 mRNA vaccines. However, the underlying immune cellular and molecular …

[PDF][PDF] Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease

L Bergamaschi, F Mescia, L Turner, AL Hanson… - Immunity, 2021 - cell.com
The kinetics of the immune changes in COVID-19 across severity groups have not been
rigorously assessed. Using immunophenotyping, RNA sequencing, and serum cytokine …

SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis

T Boettler, B Csernalabics, H Salié, H Luxenburger… - Journal of …, 2022 - Elsevier
Background & Aims Autoimmune hepatitis episodes have been described following SARS-
CoV-2 infection and vaccination but their pathophysiology remains unclear. Herein, we …

[HTML][HTML] Post-acute sequelae of COVID-19 is characterized by diminished peripheral CD8+β7 integrin+ T cells and anti-SARS-CoV-2 IgA response

A Santa Cruz, A Mendes-Frias… - Nature …, 2023 - nature.com
Several millions of individuals are estimated to develop post-acute sequelae SARS-CoV-2
condition (PASC) that persists for months after infection. Here we evaluate the immune …

Significance of bystander T cell activation in microbial infection

H Lee, S Jeong, EC Shin - Nature Immunology, 2022 - nature.com
During microbial infection, pre-existing memory CD8+ T cells that are not specific for the
infecting pathogens can be activated by cytokines without cognate antigens, termed …

[HTML][HTML] The activation of bystander CD8+ T cells and their roles in viral infection

TS Kim, EC Shin - Experimental & molecular medicine, 2019 - nature.com
During viral infections, significant numbers of T cells are activated in a T cell receptor-
independent and cytokine-dependent manner, a phenomenon referred to as “bystander …

[PDF][PDF] STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation

E Masle-Farquhar, KJL Jackson, TJ Peters, G Al-Eryani… - Immunity, 2022 - cell.com
The association between cancer and autoimmune disease is unexplained, exemplified by T
cell large granular lymphocytic leukemia (T-LGL) where gain-of-function (GOF) somatic …

IL‐18 and infections: Is there a role for targeted therapies?

A Vecchie, A Bonaventura, S Toldo… - Journal of cellular …, 2021 - Wiley Online Library
Abstract Interleukin (IL)‐18 is a pro‐inflammatory cytokine belonging to the IL‐1 family, first
identified for its interferon‐γ‐inducing properties. IL‐18 regulates both T helper (Th) 1 and …