Cancer-specific T cells are required for effective anti-cancer immunity and have a central
role in cancer immunotherapy. However, emerging evidence suggests that only a small …

Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in
tissues. TRM form an integral part of the immune sensing network and have the ability to …

Rare immune-mediated cardiac tissue inflammation can occur after vaccination, including
after SARS-CoV-2 mRNA vaccines. However, the underlying immune cellular and molecular …

The kinetics of the immune changes in COVID-19 across severity groups have not been
rigorously assessed. Using immunophenotyping, RNA sequencing, and serum cytokine …

Background & Aims Autoimmune hepatitis episodes have been described following SARS-
CoV-2 infection and vaccination but their pathophysiology remains unclear. Herein, we …

Several millions of individuals are estimated to develop post-acute sequelae SARS-CoV-2
condition (PASC) that persists for months after infection. Here we evaluate the immune …

During microbial infection, pre-existing memory CD8+ T cells that are not specific for the
infecting pathogens can be activated by cytokines without cognate antigens, termed …

During viral infections, significant numbers of T cells are activated in a T cell receptor-
independent and cytokine-dependent manner, a phenomenon referred to as “bystander …

The association between cancer and autoimmune disease is unexplained, exemplified by T
cell large granular lymphocytic leukemia (T-LGL) where gain-of-function (GOF) somatic …

Abstract Interleukin (IL)‐18 is a pro‐inflammatory cytokine belonging to the IL‐1 family, first
identified for its interferon‐γ‐inducing properties. IL‐18 regulates both T helper (Th) 1 and …