[HTML][HTML] Role of animal models in biomedical research: a review
The animal model deals with the species other than the human, as it can imitate the disease
progression, its' diagnosis as well as a treatment similar to human. Discovery of a drug …
progression, its' diagnosis as well as a treatment similar to human. Discovery of a drug …
[HTML][HTML] The proteolysis of ECM in intervertebral disc degeneration
Intervertebral disc (IVD) degeneration (IDD) is a pathological process that commonly occurs
throughout the human life span and is a major cause of lower back pain. Better elucidation …
throughout the human life span and is a major cause of lower back pain. Better elucidation …
[HTML][HTML] Immuno-modulatory effects of intervertebral disc cells
P Bermudez-Lekerika, KB Crump… - Frontiers in cell and …, 2022 - frontiersin.org
Low back pain is a highly prevalent, chronic, and costly medical condition predominantly
triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and …
triggered by intervertebral disc degeneration (IDD). IDD is often caused by structural and …
[HTML][HTML] Gut-disc axis: A cause of intervertebral disc degeneration and low back pain?
Purpose Low back pain (LBP), a widely prevalent and costly disease around the world, is
mainly caused by intervertebral disc (IVD) degeneration (IDD). Although numerous factors …
mainly caused by intervertebral disc (IVD) degeneration (IDD). Although numerous factors …
[HTML][HTML] The mechanisms and functions of IL-1β in intervertebral disc degeneration
H Li, X Wang, H Pan, C Xiao, C Wang, S Guo… - Experimental …, 2023 - Elsevier
Intervertebral disc degeneration (IDD) is the leading cause of low back pain (LBP) and
disability in the elderly, imposing significant public health and economic burden worldwide …
disability in the elderly, imposing significant public health and economic burden worldwide …
[HTML][HTML] Emerging tissue engineering strategies for annulus fibrosus therapy
A Zhang, Z Cheng, Y Chen, P Shi, W Gan, Y Zhang - Acta Biomaterialia, 2023 - Elsevier
Low back pain is a major public health concern experienced by 80% of the world's
population during their lifetime, which is closely associated with intervertebral disc (IVD) …
population during their lifetime, which is closely associated with intervertebral disc (IVD) …
A comprehensive tool box for large animal studies of intervertebral disc degeneration
NN Lee, E Salzer, FC Bach, AF Bonilla, JL Cook… - JOR …, 2021 - Wiley Online Library
Preclinical studies involving large animal models aim to recapitulate the clinical situation as
much as possible and bridge the gap from benchtop to bedside. To date, studies …
much as possible and bridge the gap from benchtop to bedside. To date, studies …
Combined hydrogel and mesenchymal stem cell therapy for moderate-severity disc degeneration in goats
C Zhang, SE Gullbrand, TP Schaer… - … Engineering Part A, 2021 - liebertpub.com
Intervertebral disc degeneration is a cascade of cellular, structural, and biomechanical
changes that is strongly implicated as a cause of low-back pain. Current treatment strategies …
changes that is strongly implicated as a cause of low-back pain. Current treatment strategies …
Preclinical in vivo animal models of intervertebral disc degeneration. Part 1: a systematic review
Intervertebral disc degeneration (IVDD), a widely recognized cause of lower back pain, is
the leading cause of disability worldwide. A myriad of preclinical in vivo animal models of …
the leading cause of disability worldwide. A myriad of preclinical in vivo animal models of …
[HTML][HTML] USP14 promotes pyroptosis of human annulus fibrosus cells derived from patients with intervertebral disc degeneration through deubiquitination of NLRP3 …
B Hai, T Mao, C Du, F Jia, Y Liu, Q Song… - Acta Biochimica et …, 2022 - ncbi.nlm.nih.gov
Intervertebral disc degeneration (IVDD) is a general disorder that results in low back pain
and disability among many affected individuals. However, the current treatments for IVDD …
and disability among many affected individuals. However, the current treatments for IVDD …