Human mitochondrial (mt) ATP synthase, or complex V consists of two functional domains: F
1, situated in the mitochondrial matrix, and F o, located in the inner mitochondrial …

Mitochondria are the power stations of the eukaryotic cell, using the energy released by the
oxidation of glucose and other sugars to produce ATP. Electrons are transferred from NADH …

The diarylquinoline TMC207 kills Mycobacterium tuberculosis by specifically inhibiting ATP
synthase. We show here that human mitochondrial ATP synthase (50% inhibitory …

Assembly of the oxidative phosphorylation (OXPHOS) system in the mitochondrial inner
membrane is an intricate process in which many factors must interact. The OXPHOS system …

mTOR inhibition is beneficial in neurodegenerative disease models and its effects are often
attributable to the modulation of autophagy and anti-apoptosis. Here, we report a neglected …

Devastating human neuromuscular disorders have been associated to defects in the ATP
synthase. This enzyme is found in the inner mitochondrial membrane and catalyzes the last …

Dysfunction of mitochondria is frequently proposed to be involved in neurodegenerative
disease. Deficiencies in energy supply, free radical generation, Ca2+ buffering or control of …

Mitochondrial diseases are severe and largely untreatable. Owing to the many essential
processes carried out by mitochondria and the complex cellular systems that support these …

Mitochondrial dysfunction and dysregulation of apoptosis are implicated in many diseases
such as cancer and neurodegeneration. We investigate here the role of respiratory chain …

In mammals, the majority of cellular ATP is produced by the mitochondrial F1FO-ATP
synthase through an elaborate catalytic mechanism. While most subunits of this enzymatic …