Multi‐omic strategies applied to the study of pharmacoresistance in mesial temporal lobe epilepsy

EM Bruxel, AM do Canto, DCF Bruno… - Epilepsia …, 2022 - Wiley Online Library
Mesial temporal lobe epilepsy (MTLE) is the most common type of focal epilepsy in adults,
and hippocampal sclerosis (HS) is a frequent histopathological feature in patients with …

Perspectives on treatment options for mesial temporal lobe epilepsy with hippocampal sclerosis

C Palleria, A Coppola, R Citraro… - Expert Opinion on …, 2015 - Taylor & Francis
Introduction: Mesial temporal lobe epilepsy associated with hippocampal sclerosis (MTLE-
HS) is a syndrome that is often refractory to drug treatment. The effects on specific …

Multimodal data and machine learning for surgery outcome prediction in complicated cases of mesial temporal lobe epilepsy

N Memarian, S Kim, S Dewar, J Engel Jr… - Computers in biology and …, 2015 - Elsevier
Background This study sought to predict postsurgical seizure freedom from pre-operative
diagnostic test results and clinical information using a rapid automated approach, based on …

Antiepileptic drug response in temporal lobe epilepsy: a clinical and MRI morphometry study

E Bilevicius, CL Yasuda, MS Silva, CAM Guerreiro… - Neurology, 2010 - AAN Enterprises
Objective: To investigate the relationship between brain MRI and clinical characteristics and
patterns of antiepileptic drug (AED) response in patients with mesial temporal lobe epilepsy …

Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis

G Androsova, R Krause, M Borghei, M Wassenaar… - …, 2017 - Wiley Online Library
Objective Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE‐HS) is a
common epilepsy syndrome that is often poorly controlled by antiepileptic drug (AED) …

Pharmacoresistance with newer anti-epileptic drugs in mesial temporal lobe epilepsy with hippocampal sclerosis

MS Pohlen, J Jin, RS Tobias, A Maheshwari - Epilepsy research, 2017 - Elsevier
This study aims to evaluate the overall prognosis, prognostic factors, and efficacy of
treatment in patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE …

Focal epilepsies in adult patients attending two epilepsy centers: classification of drug‐resistance, assessment of risk factors, and usefulness of “new” antiepileptic …

I Gilioli, A Vignoli, E Visani, M Casazza… - …, 2012 - Wiley Online Library
Purpose: To classify the grade of antiepileptic drug (AED) resistance in a cohort of patients
with focal epilepsies, to recognize the risk factors for AED resistance, and to estimate the …

Central auditory processing impairment in patients with temporal lobe epilepsy

MW Han, JH Ahn, JK Kang, EM Lee, JH Lee, JH Bae… - Epilepsy & Behavior, 2011 - Elsevier
In temporal lobe epilepsy (TLE) there may be functional abnormalities or structural lesions
that can manifest as a central auditory processing disorder, which is defined as a disorder in …

A prediction algorithm for drug response in patients with mesial temporal lobe epilepsy based on clinical and genetic information

MS Silva-Alves, R Secolin, BS Carvalho, CL Yasuda… - PLoS …, 2017 - journals.plos.org
Mesial temporal lobe epilepsy is the most common form of adult epilepsy in surgical series.
Currently, the only characteristic used to predict poor response to clinical treatment in this …

[HTML][HTML] Factors predicting the outcome following medical treatment of mesial temporal epilepsy with hippocampal sclerosis

J Sànchez, M Centanaro, J Solís, F Delgado, L Yépez - Seizure, 2014 - Elsevier
Purpose There is a lack of information from South America regarding factors that predict the
clinical outcomes of patients treated medically for mesial temporal lobe epilepsy with …