Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles
Ionizable lipid nanoparticles (LNPs) are the most clinically advanced nano‐delivery system
for therapeutic nucleic acids. The great effort put in the development of ionizable lipids with …
for therapeutic nucleic acids. The great effort put in the development of ionizable lipids with …
Polymersome-based protein drug delivery–quo vadis?
MG Gouveia, JP Wesseler, J Ramaekers… - Chemical Society …, 2023 - pubs.rsc.org
Protein-based therapeutics are an attractive alternative to established therapeutic
approaches and represent one of the fastest growing families of drugs. While many of these …
approaches and represent one of the fastest growing families of drugs. While many of these …
Endosomal escape: A bottleneck for LNP-mediated therapeutics
S Chatterjee, E Kon, P Sharma… - Proceedings of the …, 2024 - National Acad Sciences
Lipid nanoparticles (LNPs) have recently emerged as a powerful and versatile clinically
approved platform for nucleic acid delivery, specifically for mRNA vaccines. A major …
approved platform for nucleic acid delivery, specifically for mRNA vaccines. A major …
The endosomal escape of nanoparticles: toward more efficient cellular delivery
SA Smith, LI Selby, APR Johnston… - Bioconjugate …, 2018 - ACS Publications
Many emerging therapies rely on the delivery of biological cargo into the cytosol.
Nanoparticle delivery systems hold great potential to deliver these therapeutics but are …
Nanoparticle delivery systems hold great potential to deliver these therapeutics but are …
Functional nucleic acids-engineered bio-barcode nanoplatforms for targeted synergistic therapy of multidrug-resistant cancer
S Zhi, X Zhang, J Zhang, X Wang, S Bi - ACS nano, 2023 - ACS Publications
Rational design of multifunctional nanomedicines has revolutionized the therapeutic efficacy
of cancers. Herein, we have constructed the functional nucleic acids (FNAs)-engineered …
of cancers. Herein, we have constructed the functional nucleic acids (FNAs)-engineered …
Delivery of oligonucleotide therapeutics: chemical modifications, lipid nanoparticles, and extracellular vesicles
Oligonucleotides (ONs) comprise a rapidly growing class of therapeutics. In recent years, the
list of FDA-approved ON therapies has rapidly expanded. ONs are small (15–30 bp) …
list of FDA-approved ON therapies has rapidly expanded. ONs are small (15–30 bp) …
Stimuli-responsive drug delivery systems triggered by intracellular or subcellular microenvironments
T Sun, C Jiang - Advanced Drug Delivery Reviews, 2023 - Elsevier
Drug delivery systems (DDS) triggered by local microenvironment represents the state-of-art
of nanomedicine design, where the triggering hallmarks at intracellular and subcellular …
of nanomedicine design, where the triggering hallmarks at intracellular and subcellular …
Brief update on endocytosis of nanomedicines
The complexity of nanoscale interactions between biomaterials and cells has limited the
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …
realization of the ultimate vision of nanotechnology in diagnostics and therapeutics. As such …
Visualization of the process of a nanocarrier-mediated gene delivery: stabilization, endocytosis and endosomal escape of genes for intracellular spreading
Z Ma, Y Zheng, Z Chao, H Chen, Y Zhang… - Journal of …, 2022 - Springer
Nanoparticles have been widely applied as gene carrier for improving RNA interference
(RNAi) efficiency in medical and agricultural fields. However, the mechanism and delivery …
(RNAi) efficiency in medical and agricultural fields. However, the mechanism and delivery …
[HTML][HTML] Polyethylenimine (PEI) in gene therapy: Current status and clinical applications
J Casper, SH Schenk, E Parhizkar, P Detampel… - Journal of Controlled …, 2023 - Elsevier
Polyethlyenimine (PEI) was introduced 1995 as a cationic polymer for nucleic acid delivery.
PEI and its derivatives are extensively used in basic research and as reference formulations …
PEI and its derivatives are extensively used in basic research and as reference formulations …