On the rise and fall of the apnea− hypopnea index: A historical review and critical appraisal

DA Pevernagie, B Gnidovec‐Strazisar… - Journal of sleep …, 2020 - Wiley Online Library
Summary The publication of “The Sleep Apnea Syndromes” by Guilleminault et al. in the
1970s hallmarked the discovery of a new disease entity involving serious health …

Global burden of sleep‐disordered breathing and its implications

MM Lyons, NY Bhatt, AI Pack, UJ Magalang - Respirology, 2020 - Wiley Online Library
One‐seventh of the world's adult population, or approximately one billion people, are
estimated to have OSA. Over the past four decades, obesity, the main risk factor for OSA, has …

Sleep apnea–specific hypoxic burden, symptom subtypes, and risk of cardiovascular events and all-cause mortality

W Trzepizur, M Blanchard, T Ganem… - American journal of …, 2022 - atsjournals.org
Rationale: Data from population-based cohorts suggest that symptom subtypes and
obstructive sleep apnea (OSA)–specific hypoxic burden (HB) could help to better identify …

Symptom subtypes of obstructive sleep apnea predict incidence of cardiovascular outcomes

DR Mazzotti, BT Keenan, DC Lim… - American journal of …, 2019 - atsjournals.org
Rationale: Symptom subtypes have been described in clinical and population samples of
patients with obstructive sleep apnea (OSA). It is unclear whether these subtypes have …

Obstructive sleep apnea: transition from pathophysiology to an integrative disease model

WT McNicholas, D Pevernagie - Journal of sleep research, 2022 - Wiley Online Library
Obstructive sleep apnea (OSA) is characterised by recurring episodes of upper airway
obstruction during sleep and the fundamental abnormality reflects the inability of the upper …

International consensus statement on obstructive sleep apnea

JL Chang, AN Goldberg, JA Alt… - International forum of …, 2023 - Wiley Online Library
Background Evaluation and interpretation of the literature on obstructive sleep apnea (OSA)
allows for consolidation and determination of the key factors important for clinical …

Phenotypic subtypes of OSA: a challenge and opportunity for precision medicine

A Zinchuk, HK Yaggi - Chest, 2020 - Elsevier
Current strategies for the management of OSA reflect a one-size-fits-all approach. Diagnosis
and severity of OSA are based on the apnea-hypopnea index and treatment initiated with …

Randomized clinical trials of cardiovascular disease in obstructive sleep apnea: understanding and overcoming bias

AI Pack, UJ Magalang, B Singh, ST Kuna, BT Keenan… - Sleep, 2021 - academic.oup.com
Three recent randomized control trials (RCTs) found that treatment of obstructive sleep
apnea (OSA) with continuous positive airway pressure (CPAP) did not reduce rates of future …

More than the sum of the respiratory events: personalized medicine approaches for obstructive sleep apnea

BA Edwards, S Redline, SA Sands… - American journal of …, 2019 - atsjournals.org
Traditionally, the presence and severity of obstructive sleep apnea (OSA) have been defined
by the apnea–hypopnea index (AHI). Continuous positive airway pressure is generally first …

Precision medicine in obstructive sleep apnoea

MA Martinez-Garcia, F Campos-Rodriguez… - The Lancet …, 2019 - thelancet.com
Obstructive sleep apnoea (OSA) is a heterogeneous and complex disease; however,
diagnosis and management still rely on a simple set of tools and few therapeutic options …