For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) can induce apoptosis
in a wide variety of cancer cells, both in vitro and in vivo, importantly without killing any …

Adenosine monophosphate–activated protein kinase (AMPK) activity is stimulated to
promote metabolic adaptation upon energy stress. However, sustained metabolic stress may …

The discovery that the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) can
induce apoptosis of cancer cells without causing toxicity in mice has led to the in-depth study …

In medicine, nanotechnology has sparked a rapidly growing interest as it promises to solve a
number of issues associated with conventional therapeutic agents, including their poor …

Oxidative stress caused by an imbalanced metabolism and an excess of reactive oxygen
species (ROS) lead to a range of health disorders in humans. Our endogenous antioxidant …

Unlike other members of the TNF superfamily, the TNF-related apoptosis-inducing ligand
(TRAIL, also known as Apo2L) possesses the unique capacity to induce apoptosis …

REVIEW Apoptosis is a cell suicide mechanism that enables metazoans to control cell
number in tissues and to eliminate individual cells that threaten the animal's survival. Certain …

Abstract Tumour Necrosis Factor α (TNFα), is an inflammatory cytokine produced by
macrophages/monocytes during acute inflammation and is responsible for a diverse range …

In the last decade, basic cancer research has produced remarkable advances in our
understanding of cancer biology and cancer genetics. Among the most important of these …