GRAND: a database of gene regulatory network models across human conditions
M Ben Guebila, CM Lopes-Ramos… - Nucleic Acids …, 2022 - academic.oup.com
Gene regulation plays a fundamental role in shaping tissue identity, function, and response
to perturbation. Regulatory processes are controlled by complex networks of interacting …
to perturbation. Regulatory processes are controlled by complex networks of interacting …
The Network Zoo: a multilingual package for the inference and analysis of gene regulatory networks
Inference and analysis of gene regulatory networks (GRNs) require software that integrates
multi-omic data from various sources. The Network Zoo (netZoo; netzoo. github. io) is a …
multi-omic data from various sources. The Network Zoo (netZoo; netzoo. github. io) is a …
Advancing Biomedicine with Graph Representation Learning: Recent Progress, Challenges, and Future Directions
Objectives: Graph representation learning (GRL) has emerged as a pivotal field that has
contributed significantly to breakthroughs in various fields, including biomedicine. The …
contributed significantly to breakthroughs in various fields, including biomedicine. The …
Bayesian inference of sample-specific coexpression networks
Gene regulatory networks (GRNs) are effective tools for inferring complex interactions
between molecules that regulate biological processes and hence can provide insights into …
between molecules that regulate biological processes and hence can provide insights into …
Network-based drug repurposing for schizophrenia
Despite recent progress, the challenges in drug discovery for schizophrenia persist.
However, computational drug repurposing has gained popularity as it leverages the wealth …
However, computational drug repurposing has gained popularity as it leverages the wealth …
Deep learning in gene regulatory network inference: a survey
J Dong, J Li, F Wang - IEEE/ACM Transactions on …, 2024 - ieeexplore.ieee.org
Understanding the intricate regulatory relationships among genes is crucial for
comprehending the development, differentiation, and cellular response in living systems …
comprehending the development, differentiation, and cellular response in living systems …
Higher-order correction of persistent batch effects in correlation networks
Motivation Systems biology analyses often use correlations in gene expression profiles to
infer co-expression networks that are then used as input for gene regulatory network …
infer co-expression networks that are then used as input for gene regulatory network …
Biologically informed NeuralODEs for genome-wide regulatory dynamics
Background Gene regulatory network (GRN) models that are formulated as ordinary
differential equations (ODEs) can accurately explain temporal gene expression patterns and …
differential equations (ODEs) can accurately explain temporal gene expression patterns and …
[HTML][HTML] Use of gene regulatory network analysis to repurpose drugs to treat bipolar disorder
TTT Truong, ZSJ Liu, B Panizzutti, OM Dean… - Journal of Affective …, 2024 - Elsevier
Background Bipolar disorder (BD) presents significant challenges in drug discovery,
necessitating alternative approaches. Drug repurposing, leveraging computational …
necessitating alternative approaches. Drug repurposing, leveraging computational …
[PDF][PDF] Pruning neural network models for gene regulatory dynamics using data and domain knowledge
The practical utility of machine learning models in the sciences often hinges on their
interpretability. It is common to assess a model's merit for scientific discovery, and thus novel …
interpretability. It is common to assess a model's merit for scientific discovery, and thus novel …