GRAND: a database of gene regulatory network models across human conditions

M Ben Guebila, CM Lopes-Ramos… - Nucleic Acids …, 2022 - academic.oup.com
Gene regulation plays a fundamental role in shaping tissue identity, function, and response
to perturbation. Regulatory processes are controlled by complex networks of interacting …

The Network Zoo: a multilingual package for the inference and analysis of gene regulatory networks

M Ben Guebila, T Wang, CM Lopes-Ramos, V Fanfani… - Genome Biology, 2023 - Springer
Inference and analysis of gene regulatory networks (GRNs) require software that integrates
multi-omic data from various sources. The Network Zoo (netZoo; netzoo. github. io) is a …

Advancing Biomedicine with Graph Representation Learning: Recent Progress, Challenges, and Future Directions

F Li, Y Nian, Z Sun, C Tao - Yearbook of Medical Informatics, 2023 - thieme-connect.com
Objectives: Graph representation learning (GRL) has emerged as a pivotal field that has
contributed significantly to breakthroughs in various fields, including biomedicine. The …

Bayesian inference of sample-specific coexpression networks

E Saha, V Fanfani, P Mandros, MB Guebila… - Genome …, 2024 - genome.cshlp.org
Gene regulatory networks (GRNs) are effective tools for inferring complex interactions
between molecules that regulate biological processes and hence can provide insights into …

Network-based drug repurposing for schizophrenia

TTT Truong, ZSJ Liu, B Panizzutti, JH Kim… - …, 2024 - nature.com
Despite recent progress, the challenges in drug discovery for schizophrenia persist.
However, computational drug repurposing has gained popularity as it leverages the wealth …

Deep learning in gene regulatory network inference: a survey

J Dong, J Li, F Wang - IEEE/ACM Transactions on …, 2024 - ieeexplore.ieee.org
Understanding the intricate regulatory relationships among genes is crucial for
comprehending the development, differentiation, and cellular response in living systems …

Higher-order correction of persistent batch effects in correlation networks

S Micheletti, D Schlauch, J Quackenbush… - …, 2024 - academic.oup.com
Motivation Systems biology analyses often use correlations in gene expression profiles to
infer co-expression networks that are then used as input for gene regulatory network …

Biologically informed NeuralODEs for genome-wide regulatory dynamics

I Hossain, V Fanfani, J Fischer, J Quackenbush… - Genome Biology, 2024 - Springer
Background Gene regulatory network (GRN) models that are formulated as ordinary
differential equations (ODEs) can accurately explain temporal gene expression patterns and …

[HTML][HTML] Use of gene regulatory network analysis to repurpose drugs to treat bipolar disorder

TTT Truong, ZSJ Liu, B Panizzutti, OM Dean… - Journal of Affective …, 2024 - Elsevier
Background Bipolar disorder (BD) presents significant challenges in drug discovery,
necessitating alternative approaches. Drug repurposing, leveraging computational …

[PDF][PDF] Pruning neural network models for gene regulatory dynamics using data and domain knowledge

I Hossain, J Fischer, R Burkholz… - 38th Conference on …, 2024 - pure.mpg.de
The practical utility of machine learning models in the sciences often hinges on their
interpretability. It is common to assess a model's merit for scientific discovery, and thus novel …