The central nervous system (CNS) influences the immune system generally by regulating
the systemic concentration of humoral substances (eg, cortisol and epinephrine), whereas …

Introduction Chemotherapy-induced peripheral neuropathy (CIPN) is a common
consequence of cancer treatment and pain is a frequent complaint of the patients. Paclitaxel …

Mechanisms of sex-dependent orofacial pain are widely understudied. A significant gap in
knowledge exists about comprehensive regulation of tissue-specific trigeminal sensory …

Background Neuropeptides play a critical role in regulating pain and inflammation. Despite
accumulating evidence has further uncovered the novel functions and mechanisms of …

Neuropathic pain (NP) is a common debilitating chronic pain condition with limited effective
therapeutics. Further investigating mechanisms underlying NP is therefore of great …

The CNS exists in a privileged space that is protected by the existence of the blood–brain
barrier (BBB). The BBB prevents detrimental blood constituents from accessing the brain …

Simple Summary Tendon injuries lead to poor healing with scarring and occasionally
calcification. In these metaplastic drifts, mice with injured Achilles tendons (ATs) represent a …

Pain-sensing neurons detect environmental insults and tissue injury, driving avoidance
behavior and the local release of neuropeptides. Two related papers in this issue of Cell …

Neuropathic pain is a devastating condition where current therapeutics offer little to no pain
relief. Novel nonnarcotic therapeutic targets are needed to address this growing medical …

Abstract Calcium (Ca 2+) is essential for diverse cellular functions, where intracellular Ca 2+
concentrations are regulated by various pumps, ion channels, and ion exchangers. Basal …