[HTML][HTML] Recent advances on drug development and emerging therapeutic agents for Alzheimer's disease
T Athar, K Al Balushi, SA Khan - Molecular biology reports, 2021 - Springer
Alzheimer's disease (AD) is a neurodegenerative old age disease that is complex,
multifactorial, unalterable, and progressive in nature. The currently approved therapy …
multifactorial, unalterable, and progressive in nature. The currently approved therapy …
[HTML][HTML] Advances in Alzheimer's disease's pharmacological treatment
CE Conti Filho, LB Loss… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) is the most common type of dementia in the elderly. Several
hypotheses emerged from AD pathophysiological mechanisms. However, no neuronal …
hypotheses emerged from AD pathophysiological mechanisms. However, no neuronal …
A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease
Alzheimer's disease (AD) is an age-related multifactorial neurodegenerative disorder
characterized by severe central cholinergic neuronal loss, gradually contributing to cognitive …
characterized by severe central cholinergic neuronal loss, gradually contributing to cognitive …
Exploring diverse frontiers: Advancements of bioactive 4-aminoquinoline-based molecular hybrids in targeted therapeutics and beyond
Amongst heterocyclic compounds, quinoline and its derivatives are advantaged scaffolds
that appear as a significant assembly motif for developing new drug entities. Aminoquinoline …
that appear as a significant assembly motif for developing new drug entities. Aminoquinoline …
Machine learning-based modeling to predict inhibitors of acetylcholinesterase
Acetylcholinesterase enzyme is responsible for the degradation of acetylcholine and is an
important drug target for the treatment of Alzheimer's disease. When this enzyme is inhibited …
important drug target for the treatment of Alzheimer's disease. When this enzyme is inhibited …
Multicomponent Petasis reaction for the identification of pyrazine based multi-target directed anti-Alzheimer's agents: In-silico design, synthesis, and characterization
Multi-target directed ligands (MTDLs) have recently attracted significant interest due to their
exceptional effectiveness against multi-factorial Alzheimer's disease. The present work …
exceptional effectiveness against multi-factorial Alzheimer's disease. The present work …
[HTML][HTML] The potential of a stratified approach to drug repurposing in Alzheimer's disease
C Anderson, M Bucholc, PL McClean, SD Zhang - Biomolecules, 2023 - mdpi.com
Alzheimer's disease (AD) is a complex neurodegenerative condition that is characterized by
the build-up of amyloid-beta plaques and neurofibrillary tangles. While multiple theories …
the build-up of amyloid-beta plaques and neurofibrillary tangles. While multiple theories …
[HTML][HTML] Repurposing of FDA-approved drugs as dual-acting MAO-B and AChE inhibitors against Alzheimer's disease: An in silico and in vitro study
An in silico consensus molecular docking approach and in vitro evaluations were adopted in
the present study to explore a dataset of FDA-approved drugs as novel multitarget MAO …
the present study to explore a dataset of FDA-approved drugs as novel multitarget MAO …
Trimethoxyflavones from Ocimum basilicum L. leaves improve long term memory in mice by modulating multiple pathways
Abstract Ethnopharmacological relevance Traditionally, Ocimum basilicum L. leaves (OB)
are recommended for various brain disorders. Aim of the study Scientific evidence highlights …
are recommended for various brain disorders. Aim of the study Scientific evidence highlights …
Further SAR studies on natural template based neuroprotective molecules for the treatment of Alzheimer's disease
In our earlier paper, we described ferulic acid (FA) template based novel series of
multifunctional cholinesterase (ChE) inhibitors for the management of AD. This report has …
multifunctional cholinesterase (ChE) inhibitors for the management of AD. This report has …