Pancreatic β-cell failure and death contribute significantly to the pathogenesis of type 2
diabetes. One of the main factors responsible for β-cell dysfunction and subsequent cell …

Perioperative organ injury remains a medical, social and economic problem in cardiac
surgery. Patients with postoperative organ dysfunction have increases in morbidity, length of …

The prevalence of type 2 diabetes (T2D) is increasing worldwide. Decreased nitric oxide
(NO) bioavailability is involved in the pathophysiology of T2D and its complications. l …

Nitric oxide (NO) is a gas that serves as a ubiquitous signaling molecule participating in
physiological activities of various organ systems. Nitric oxide is produced in the endocrine …

Background Although recent studies indicate that renal ischemic preconditioning (IPC)
protects the kidney from ischemia-reperfusion (I/R) injury, the precise protective mechanism …

Baicalin, the main active ingredient of the Scutellaria root, exerts anti-oxidant and anti-
apoptotic effects in cardiovascular diseases. However, the therapeutic mechanism of …

Proinflammatory cytokines produced by immune cells destroy pancreatic beta cells in type 1
diabetes. The aim of this study was to investigate the cytokine network and its effects in …

In type 2 diabetes, the β‐cell is exposed to chronic hyperglycaemia, which increases its
metabolic activity, with excess generation of reactive oxygen species (ROS) as a …

An involvement of inducible nitric oxide (NO) synthase (NOS) in pancreatic b-cell
degeneration during the process of type 1 diabetes has been well discussed. Recently …

Pancreatic β-cell dysfunction is central to type 2 diabetes pathogenesis. Prolonged elevated
levels of circulating free-fatty acids and hyperglycemia, also termed glucolipotoxicity …