Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies
BF Haynes, K Wiehe, P Borrow, KO Saunders… - Nature Reviews …, 2023 - nature.com
After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive.
There are many reasons why the development of a potent and durable HIV-1 vaccine is …
There are many reasons why the development of a potent and durable HIV-1 vaccine is …
Eliciting B cell immunity against infectious diseases using nanovaccines
A Singh - Nature nanotechnology, 2021 - nature.com
Infectious diseases, including the coronavirus disease 2019 (COVID-19) pandemic that has
brought the world to a standstill, are emerging at an unprecedented rate with a substantial …
brought the world to a standstill, are emerging at an unprecedented rate with a substantial …
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection
Broadly neutralizing antibodies (bnAbs) to coronaviruses (CoVs) are valuable in their own
right as prophylactic and therapeutic reagents to treat diverse CoVs and as templates for …
right as prophylactic and therapeutic reagents to treat diverse CoVs and as templates for …
Clonal replacement sustains long-lived germinal centers primed by respiratory viruses
RVH de Carvalho, J Ersching, A Barbulescu, A Hobbs… - Cell, 2023 - cell.com
Germinal centers (GCs) form in secondary lymphoid organs in response to infection and
immunization and are the source of affinity-matured B cells. The duration of GC reactions …
immunization and are the source of affinity-matured B cells. The duration of GC reactions …
Somatic hypermutation introduces bystander mutations that prepare SARS-CoV-2 antibodies for emerging variants
M Korenkov, M Zehner, H Cohen-Dvashi… - Immunity, 2023 - cell.com
Somatic hypermutation (SHM) drives affinity maturation and continues over months in SARS-
CoV-2-neutralizing antibodies (nAbs). However, several potent SARS-CoV-2 antibodies …
CoV-2-neutralizing antibodies (nAbs). However, several potent SARS-CoV-2 antibodies …
Understanding early-life adaptive immunity to guide interventions for pediatric health
Infants are capable of mounting adaptive immune responses, but their ability to develop long-
lasting immunity is limited. Understanding the particularities of the neonatal adaptive …
lasting immunity is limited. Understanding the particularities of the neonatal adaptive …
[HTML][HTML] Pandemic preparedness: developing vaccines and therapeutic antibodies for COVID-19
GD Sempowski, KO Saunders, P Acharya, KJ Wiehe… - Cell, 2020 - cell.com
The SARS-CoV-2 pandemic that causes COVID-19 respiratory syndrome has caused global
public health and economic crises, necessitating rapid development of vaccines and …
public health and economic crises, necessitating rapid development of vaccines and …
Targeted selection of HIV-specific antibody mutations by engineering B cell maturation
INTRODUCTION A major goal of HIV-1 vaccine development is the design of immunogens
that induce broadly neutralizing antibodies (bnAbs). However, vaccination of humans has …
that induce broadly neutralizing antibodies (bnAbs). However, vaccination of humans has …
Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates
The development of an effective AIDS vaccine remains a challenge. Nucleoside-modified
mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be a potent mode of …
mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be a potent mode of …