The development of anti-drug antibodies (ADAs) following administration of biotherapeutics
to patients is a vexing problem that is attracting increasing attention from pharmaceutical …

Development of biotherapeutics is hampered by the inherent risk of immunogenicity, which
requires extensive clinical assessment and possible re-engineering efforts for mitigation …

Ro52/TRIM21 plays a key role in antibody-dependent pathogen neutralization and is a
major autoantigen in systemic lupus erythematosus, Sjögren's syndrome (SS), and other …

The efficacy of PD-1 monoclonals such as pembrolizumab can be modulated by the signals
delivered via their Fc region. Tumour/inflammation associated proteases can generate F …

Objective The early diagnosis of seronegative rheumatoid arthritis (SNRA), characterised by
the absence of rheumatoid factor and anti-citrullinated antibody, involves a greater …

Gene therapy for the treatment of ocular neovascularization has reached clinical trial
phases. The AAV2-sFLT01 construct was already evaluated in a phase 1 open-label trial …

The host immune system adopts multiple mechanisms involving antibodies to confront
cancer cells. Accordingly, anti-tumor mAbs have become mainstays in cancer treatment …

Cloning VH and VL genes from individual antigen-specific B cells is an attractive approach
for producing monoclonal antibodies of the desired specificity. Current RT-PCR protocols …

Vascular endothelial growth factor (VEGF) traps and VEGF mini-traps that include VEGF
receptor Ig-like domains, fused to a multimerizing component, are disclosed. The VEGF …

زمینه و هدف: ایمونوگلوبولین ها (Igs) گروهی از پروتئین های سرم هستند که نقش مهمی در دفاع علیه
میکروارگانیسم ها بر عهده دارند. ایمونوگلوبولین ها از زنجیره های سبک و سنگین تشکیل شده اند …‎