Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …

Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent
kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as …

The retinoblastoma (RB) tumour suppressor gene is functionally inactivated in a broad
range of paediatric and adult cancers, and a plethora of cellular functions and partners have …

Acute induction of oncogenic Ras provokes cellular senescence involving the
retinoblastoma (Rb) pathway, but the tumour suppressive potential of senescence in vivo …

The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-
dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates …

We performed exome sequencing to detect somatic mutations in protein-coding regions in
seven melanoma cell lines and donor-matched germline cells. All melanoma samples had …

P16INK4A (also known as P16 and MTS1), a protein consisting exclusively of four ankyrin
repeats, is recognized as a tumor suppressor mainly because of the prevalence of genetic …

Research over the past quarter century has identified cyclin D-dependent kinases, CDK4
and CDK6, as the major oncogenic drivers among members of the CDK superfamily …

The recent clinical success of targeted therapies in melanoma directed at the oncogene
BRAF validates the concept of targeting oncogenes. The p16-cyclin D-CDK4/6 …

High-grade serous ovarian carcinoma (HGSOC) is a lethal disease for which improved
screening and treatment strategies are urgently needed. Progress in these areas is impeded …