Monoamine oxidase B inhibitors based on natural privileged scaffolds: A review of systematically structural modification
Y Lv, Z Zheng, R Liu, J Guo, C Zhang, Y Xie - International Journal of …, 2023 - Elsevier
Monoamine oxidase is a flavin enzyme that catalyzes the oxidation of monoamine
neurotransmitters in the brain. Various toxic by-products, aldehydes and hydrogen peroxide …
neurotransmitters in the brain. Various toxic by-products, aldehydes and hydrogen peroxide …
A review on biological and medicinal significance of thiazoles
PM Jadhav, S Kantevari, AB Tekale… - … , Sulfur, and Silicon …, 2021 - Taylor & Francis
Thiazole, a five-membered heterocyclic compound constitutes the skeleton of various
commercially marketed drug candidates and the heart-core in a diverse range of entities of …
commercially marketed drug candidates and the heart-core in a diverse range of entities of …
Design, synthesis, mechanistic studies and in silico ADME predictions of benzimidazole derivatives as novel antifungal agents
MM Morcoss, MN El Shimaa, RA Ibrahem… - Bioorganic …, 2020 - Elsevier
Herein, novel three series of benzimidazole scaffold bearing hydrazone, 1, 2, 4-triazole and
1, 3, 4-oxadiazole moieties 1-3, 4a-j, 6a-c and 7 derivatives were designed, synthesized and …
1, 3, 4-oxadiazole moieties 1-3, 4a-j, 6a-c and 7 derivatives were designed, synthesized and …
Eco-friendly synthesis, characterization, in-silico ADMET and molecular docking analysis of novel carbazole derivatives as antibacterial and antifungal agents
In search of novel biologically potent compounds, three novel organic molecules have been
synthesized. The structures of the prepared compounds have been characterized by …
synthesized. The structures of the prepared compounds have been characterized by …
Synthesis of novel thiazolyl hydrazone derivatives as potent dual monoamine oxidase-aromatase inhibitors
The inhibitory effects of 2-thiazolyl hydrazones on monoamine oxidase enzymes are known
for a long time. In this study, a new series of 2-thiazolyl hydrazone derivatives were …
for a long time. In this study, a new series of 2-thiazolyl hydrazone derivatives were …
Design, synthesis and biological assessment of new selective COX-2 inhibitors including methyl sulfonyl moiety
Nonsteroidal anti-inflammatory drugs (NSAIDs) cause peptic lesions in the gastrointestinal
mucosa by inhibiting the cyclooxygenase-1 (COX-1) enzyme. Selective COX-2 inhibition …
mucosa by inhibiting the cyclooxygenase-1 (COX-1) enzyme. Selective COX-2 inhibition …
Expanding the anticancer potential of 1, 2, 3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases
PA Elzahhar, SM Abd El Wahab, M Elagawany… - European Journal of …, 2020 - Elsevier
Cancer is a multifactorial disorder involving multiplicity of interrelated signaling pathways
and molecular targets. To that end, a multi-target design strategy was adopted to develop …
and molecular targets. To that end, a multi-target design strategy was adopted to develop …
Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents
Alzheimer's disease (AD) is a neurological, progressive illness that typically affects the
elderly and is clinically distinguished by memory and cognitive decline. Due to a number of …
elderly and is clinically distinguished by memory and cognitive decline. Due to a number of …
In vitro and in silico evaluation of new thiazole compounds as monoamine oxidase inhibitors
New twenty compounds bearing thiazole ring (3a-3t) were designed and synthesized as
monoamine oxidase (MAO) inhibitors. The fluorometric enzyme inhibition assay was used to …
monoamine oxidase (MAO) inhibitors. The fluorometric enzyme inhibition assay was used to …
Synthesis of new hydrazone derivatives and evaluation of their monoamine oxidase inhibitory activity
A novel series of hydrazone derivatives were designed and synthesized. Their structures
were characterized by IR, 1 H NMR, 13 C NMR and HR-MS spectroscopic methods. The …
were characterized by IR, 1 H NMR, 13 C NMR and HR-MS spectroscopic methods. The …