Epigenetic mechanisms, which include DNA methylation, histone modification, and
microRNA (miRNA), can produce heritable phenotypic changes without a change in DNA …

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer,
which is characterized by the absence of estrogen receptor (ER) and progesterone receptor …

Summary DNA N 6-methyladenine (6mA) modification is the most prevalent DNA
modification in prokaryotes, but whether it exists in human cells and whether it plays a role in …

Lung, breast, colorectal, and prostate cancers are the most incident worldwide. Optimal
population-based cancer screening methods remain an unmet need, since cancer detection …

Much of the inter-individual variability in drug efficacy and risk of adverse reactions is due to
polymorphisms in genes encoding proteins involved in drug pharmacokinetics and …

There are several definitions of biomarkers. A biomarker is a characteristic that can be
objectively measured and evaluated as an indicator of a physiological as well as a …

The global burden of breast cancer (BC) is increasing significantly. This trend is caused by
several factors such as late diagnosis, limited treatment options for certain BC subtypes …

Prostate cancer (PC) includes several phenotypes, from indolent to highly aggressive
cancer. Actual diagnostic and prognostic tools have several limitations, and there is a need …

Highlights•3D cell systems show high resistance to cytotoxic treatment compared with 2D
models.•Microfluidic systems allow cost-effective analysis of cytotoxic drugs.•Integration of …

Background Colorectal cancer (CRC) remains the most common gastrointestinal cancer and
a leading cause of cancer deaths worldwide, with most showing pathologies indicating the …