Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …

Background & Aims Intrahepatic cholangiocarcinoma (ICC) is a primary liver cancer with
high aggressiveness and extremely poor prognosis. The role of circular RNAs (circRNAs) in …

As metastasis is a major cause of death in cancer patients, new anti-metastatic strategies
are needed to improve cancer therapy outcomes. Numerous pathways have been shown to …

Background Atherosclerosis (AS) is a chronic inflammatory disorder. The aim of our study
was to explore the role of circular RNA (circRNA) transmembrane 7 superfamily member 3 …

Dysregulation of alternative splicing is a feature of cancer, both in aetiology and
progression. It occurs because of mutations in splice sites or sites that regulate splicing, or …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal types of cancer due to the
relatively late diagnosis and the limited therapeutic options. Current treatment regimens …

AspH is an endoplasmic reticulum (ER) membrane-anchored 2-oxoglutarate oxygenase
whose C-terminal oxygenase and tetratricopeptide repeat (TPR) domains present in the ER …

Chronic liver injury could gradually progress to liver fibrosis, cirrhosis, and even hepatic
carcinoma without effective treatment. The massive production and activation of abnormal …

Aspartate/asparagine β‑hydroxylase (AspH) is a type II transmembrane protein that
catalyzes the post‑translational hydroxylation of definite aspartyl and asparaginyl residues in …

Epidermal growth factor-like domains (EGFDs) have important functions in cell–cell
signaling. Both secreted and cell surface human EGFDs are subject to extensive …