RAF-MEK-ERK pathway in cancer evolution and treatment
Abstract The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
Selective and noncovalent targeting of RAS mutants for inhibition and degradation
Activating mutants of RAS are commonly found in human cancers, but to date selective
targeting of RAS in the clinic has been limited to KRAS (G12C) through covalent inhibitors …
targeting of RAS in the clinic has been limited to KRAS (G12C) through covalent inhibitors …
Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant–driven tumor growth
Oncogenic RAS mutant (RASMUT) proteins have been considered undruggable via
conventional antibody regimens owing to the intracellular location restricting conventional …
conventional antibody regimens owing to the intracellular location restricting conventional …
[HTML][HTML] Targeting Ras with protein engineering
A Tomazini, JM Shifman - Oncotarget, 2023 - ncbi.nlm.nih.gov
Ras proteins are small GTPases that regulate cell growth and division. Mutations in Ras
genes are associated with many types of cancer, making them attractive targets for cancer …
genes are associated with many types of cancer, making them attractive targets for cancer …
Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders
HRAS, NRAS, and KRAS4A/KRAS4B comprise the RAS family of small GTPases that
regulate signaling pathways controlling cell proliferation, differentiation, and survival. RAS …
regulate signaling pathways controlling cell proliferation, differentiation, and survival. RAS …
Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids
S Wiechmann, P Maisonneuve, BM Grebbin… - Journal of Biological …, 2020 - ASBMB
The small GTPases H, K, and NRAS are molecular switches indispensable for proper
regulation of cellular proliferation and growth. Several mutations in the genes encoding …
regulation of cellular proliferation and growth. Several mutations in the genes encoding …
Identification of key candidate targets and pathways for the targeted treatment of leukemia stem cells of chronic myelogenous leukemia using bioinformatics analysis
H Li, L Liu, J Zhuang, C Liu, C Zhou… - … Genetics & Genomic …, 2019 - Wiley Online Library
Background Chronic myelogenous leukemia (CML) is a myeloproliferative neoplasm that
arises from the acquisition of constitutively active BCR‐ABL tyrosine kinase in hematopoietic …
arises from the acquisition of constitutively active BCR‐ABL tyrosine kinase in hematopoietic …
Protein-based Degrader Strategies against Oncogenic RAS
KM Cheah - 2023 - dspace.mit.edu
Targeted therapies have emerged as a promising cancer treatment strategy by inhibiting
proteins specific to cancer cells while preserving healthy cells. RAS proteins play a crucial …
proteins specific to cancer cells while preserving healthy cells. RAS proteins play a crucial …
[PDF][PDF] Competitive Inhibitors of Ras Effector Binding
S Wiechmann, P Maisonneuve, BM Grebbin… - Perspective, 2016 - researchgate.net
The small GTPases H, K and NRas are molecular switches that are indispensable for the
correct regulation of cellular proliferation and growth. Mutations in Ras are associated with …
correct regulation of cellular proliferation and growth. Mutations in Ras are associated with …
Novel conformation specific inhibitors of activated GTPases reveal Ras-dependency of patient-derived cancer organoids
S Wiechmann, P Maisonneuve, BM Grebbin… - bioRxiv, 2019 - biorxiv.org
Abstract The small GTPases H, K, and NRAS are molecular switches that are indispensable
for proper regulation of cellular proliferation and growth. Mutations in this family of proteins …
for proper regulation of cellular proliferation and growth. Mutations in this family of proteins …