Next-generation Vaccine Development with nanomaterials: recent advances, possibilities, and challenges

S Shetty, PC Alvarado, D Pettie… - Annual Review of …, 2024 - annualreviews.org
Nanomaterials are becoming important tools for vaccine development owing to their tunable
and adaptable nature. Unique properties of nanomaterials afford opportunities to modulate …

Therapeutic synthetic and natural materials for immunoengineering

A Slezak, K Chang, S Hossainy, A Mansurov… - Chemical Society …, 2024 - pubs.rsc.org
Immunoengineering is a rapidly evolving field that has been driving innovations in
manipulating immune system for new treatment tools and methods. The need for materials …

ROS-Scavenging Lignin-Based Tolerogenic Nanoparticle Vaccine for Treatment of Multiple Sclerosis

NM Phan, TL Nguyen, H Shin, TA Trinh, J Kim - ACS nano, 2023 - ACS Publications
Multiple sclerosis (MS) is a demyelinating autoimmune disease, in which the immune
system attacks myelin. Although systemic immunosuppressive agents have been used to …

Vaccines for immune tolerance against autoimmune disease

A Kim, F Xie, OA Abed, JJ Moon - Advanced drug delivery reviews, 2023 - Elsevier
The high prevalence and rising incidence of autoimmune diseases have become a
prominent public health issue. Autoimmune disorders result from the immune system …

Advances in dendritic cell targeting nano-delivery systems for induction of immune tolerance

G Lin, J Wang, YG Yang, Y Zhang… - Frontiers in Bioengineering …, 2023 - frontiersin.org
Dendritic cells (DCs) are the major specialized antigen-presenting cells (APCs), play a key
role in initiating the body's immune response, maintain the balance of immunity. DCs can …

Emerging strategies for nanomedicine in autoimmunity

AS Thatte, MM Billingsley, D Weissman… - Advanced Drug Delivery …, 2024 - Elsevier
Autoimmune disorders have risen to be among the most prevalent chronic diseases across
the globe, affecting approximately 5–7% of the population. As autoimmune diseases steadily …

Integration of MyD88 inhibitor into mesoporous cerium oxide nanozymes-based targeted delivery platform for enhancing treatment of ulcerative colitis

H Liu, M Ji, Y Bi, P Xiao, J Zhao, J Gou… - … Clinics and Research, 2023 - journals.lww.com
Excessive reactive oxygen species (ROS) and stressed inflammatory response are major
characteristics of ulcerative colitis, which cause disease progression and aggravation …

Bioactive metal-based nanomedicines for boosting anti-tumor immunity: Advance, challenge, and perspective

Z Pei, L Li, N Yang, S Sun, N Jiang, L Cheng - Coordination Chemistry …, 2024 - Elsevier
Metal, as an active participant in life activities, has always been at the forefront of research.
Recent studies have revealed the crucial role of metal ions in activating the anti-tumor …

Autoantigen‐Dexamethasone Conjugate‐Loaded Liposomes Halt Arthritis Development in Mice

N Benne, D Ter Braake, D Porenta… - Advanced …, 2024 - Wiley Online Library
There is no curative treatment for chronic auto‐inflammatory diseases including rheumatoid
arthritis, and current treatments can induce off‐target side effects due to systemic immune …

Understanding the Cross‐Talk between the Ceramide Biosynthetic Pathway and Mitochondrial Function in Multiple Sclerosis and Demyelinating Disorders

Amarjeet, R Babu, A Mohapatra… - Acta Neurologica …, 2023 - Wiley Online Library
Myelin is a spiral compilation of uniformly thick membranes around the axon in an
alternating fashion, and it is formed by a complicated process known as myelination. Myelin …