Brain aging is a complex process that affects everything from the subcellular to the organ
level, begins early in life, and accelerates with age. Morphologically, brain aging is primarily …

There are declines with age in speed of processing, working memory, inhibitory function,
and long-term memory, as well as decreases in brain structure size and white matter …

Background: Several sets of diagnostic criteria have been published for vascular dementia
since the 1960s. The continuing ambiguity in vascular dementia definition warrants a critical …

Relating brain tissue properties to diffusion tensor imaging (DTI) is limited when an image
voxel contains partial volume of brain tissue with free water, such as cerebrospinal fluid or …

White matter hyperintensities (WMH) are frequently divided into periventricular (PWMH) and
deep (DWMH), and the two classes have been associated with different cognitive …

Ageing causes changes to the brain size, vasculature, and cognition. The brain shrinks with
increasing age and there are changes at all levels from molecules to morphology. Incidence …

Cerebral white matter lesions (WML) encompass axonal loss and demyelination, and the
pathogenesis is assumed to be small vessel disease (SVD)-related ischemia. However …

During the course of normal aging, biological changes occur in the brain that are associated
with changes in cognitive ability. This review presents data from neuroimaging studies of …

Misdiagnosis of multiple sclerosis (MS)(the incorrect assignment of a diagnosis of MS)
remains a problem in contemporary clinical practice. Studies indicate that misdiagnosed …

Physical and cognitive exercise may prevent or delay dementia in later life but the neural
mechanisms underlying these therapeutic benefits are largely unknown. We examined …