Inducible nitric oxide synthase: Good or bad?

M Lind, A Hayes, M Caprnda, D Petrovic… - Biomedicine & …, 2017 - Elsevier
Nitric oxide synthases (NOS) are a family of isoforms responsible for the synthesis of the
potent dilator nitric oxide (NO). Expression of inducible NOS (iNOS) occurs in conditions of …

Altered nitric oxide system in cardiovascular and renal diseases

JU Lee, EH Bae, SK Ma… - Chonnam medical journal, 2016 - synapse.koreamed.org
Nitric oxide (NO) is synthesized by a family of NO synthases (NOS), including neuronal,
inducible, and endothelial NOS (n/i/eNOS). NO-mediated effects can be beneficial or …

Dr. NO and Mr. Toxic–the versatile role of nitric oxide

C Porrini, N Ramarao, SL Tran - Biological Chemistry, 2020 - degruyter.com
Nitric oxide (NO) is present in various organisms from humans, to plants, fungus and
bacteria. NO is a fundamental signaling molecule implicated in major cellular functions. The …

Nebivolol suppresses asymmetric dimethylarginine and attenuates cyclosporine-induced nephrotoxicity and endothelial dysfunction in rats

WA Hewedy, DK Mostafa - Pharmacological Reports, 2016 - Elsevier
Abstract Background Cyclosporine A (CsA)-induced nephrotoxicity is a challenging problem
complicating its chronic use in a large array of autoimmune diseases, as well as in organ …

Protective effects of Xinji′ erkang on myocardial infarction induced cardiac injury in mice

J Hu, Y Zhang, L Wang, L Ding, G Huang, G Cai… - … and alternative medicine, 2017 - Springer
Background Myocardial infarction (MI) is a major risk factor responsible for morbidity and
mortality. Xinji′ erkang (XJEK) has been clinically used as an effective medication in the …

Nebivolol ameliorated kidney damage in Zucker diabetic fatty rats by regulation of oxidative stress/NO pathway: Comparison with captopril

Y Wang, W An, F Zhang, M Niu, Y Liu… - Clinical and …, 2018 - Wiley Online Library
The aim was to evaluate the effects and mechanisms of nebivolol on renal damage in
Zucker diabetic fatty (ZDF) rats, in comparison with those of atenolol and captopril. Animals …

Nebivolol in oral subacute treatment prevents cardiac post-ischemic dysfunction in rats, but hyperthyroidism reduces this protection: mechanisms involved

MI Ragone, M Bayley, S López, RG Díaz… - Naunyn-Schmiedeberg's …, 2024 - Springer
Nebivolol could prevent dysfunction in patients suffering myocardial ischemia. However,
influence of hyperthyroidism is not known. Consequences and mechanisms of nebivolol …

Nebivolol combined with tetrahydrobiopterin affects diastolic function in spontaneously hypertensive rats via the nitric oxide/cyclic guanosine monophosphate …

X Guan, X Guan, C Lu, B Shang, Y Zhao… - BMC Pharmacology and …, 2020 - Springer
Background Hypertension is the the primary cause of diastolic heart failure. Oxidative stress
plays an important role in cardiac diastolic dysfunction caused by hypertension. The …

[PDF][PDF] Effect of nitric oxide inhalation for the treatment of neonatal pulmonary hypertension

HW Wu, ZG Li, G Liu, GZ Lu… - Eur Rev Med Pharmacol …, 2016 - europeanreview.org
4607-4611-Effect of nitric oxide inhalation for the treatment of neonatal pulmonary hypertension
Page 1 Abstract. – OBJECTIVE: To investigate the effect of nitric oxide (NO) inhalation for the …

Индуцибельная NO-синтаза как фармакологическая мишень противовоспалительной терапии: надежда не потеряна?

ММ Галагудза, ЮП Бельский… - … журнал клинической и …, 2023 - sibjcem.ru
Аннотация Обзор посвящен текущему пониманию роли оксида азота (NO) и
индуцибельной NO-синтазы в физиологических условиях и при некоторых …