[HTML][HTML] Normal and glaucomatous outflow regulation

TS Acott, JA Vranka, KE Keller, VK Raghunathan… - Progress in retinal and …, 2021 - Elsevier
Glaucoma remains only partially understood, particularly at the level of intraocular pressure
(IOP) regulation. Trabecular meshwork (TM) and Schlemm's canal inner wall endothelium …

In vivo measurement of trabecular meshwork stiffness in a corticosteroid-induced ocular hypertensive mouse model

G Li, C Lee, V Agrahari, K Wang… - Proceedings of the …, 2019 - National Acad Sciences
Ocular corticosteroids are commonly used clinically. Unfortunately, their administration
frequently leads to ocular hypertension, ie, elevated intraocular pressure (IOP), which, in …

Viscoelastic biomechanical properties of the conventional aqueous outflow pathway tissues in healthy and glaucoma human eyes

A Karimi, R Razaghi, S Padilla, SM Rahmati… - Journal of clinical …, 2022 - mdpi.com
Background: Although the tissues comprising the ocular conventional outflow pathway have
shown strong viscoelastic mechanical response to aqueous humor pressure dynamics, the …

Developing an experimental-computational workflow to study the biomechanics of the human conventional aqueous outflow pathway

A Karimi, S Khan, R Razaghi, SM Rahmati, M Gathara… - Acta Biomaterialia, 2023 - Elsevier
The aqueous humor actively interacts with the trabecular meshwork (TM), juxtacanalicular
tissue (JCT), and Schlemm's canal (SC) through a dynamic fluid-structure interaction (FSI) …

Analysis of the effects of finite element type within a 3D biomechanical model of a human optic nerve head and posterior pole

A Karimi, R Grytz, SM Rahmati, CA Girkin… - Computer methods and …, 2021 - Elsevier
Background and objective Biomechanical stresses and strains can be simulated in the optic
nerve head (ONH) using the finite element (FE) method, and various element types have …

[HTML][HTML] A Gaussian process approach for rapid evaluation of skin tension

M Nagle, HC Broderick, C Vedel, M Destrade, M Fop… - Acta Biomaterialia, 2024 - Elsevier
Skin tension plays a pivotal role in clinical settings, it affects scarring, wound healing and
skin necrosis. Despite its importance, there is no widely accepted method for assessing in …

Segmental biomechanics of the normal and glaucomatous human aqueous outflow pathway

A Karimi, S Khan, R Razaghi, M Aga, SM Rahmati… - Acta Biomaterialia, 2024 - Elsevier
The conventional aqueous outflow pathway, encompassing the trabecular meshwork (TM),
juxtacanalicular connective tissue (JCT), and inner wall endothelium of Schlemm's canal …

A machine learning approach to predict in vivo skin growth

M Nagle, H Conroy Broderick, A Buganza Tepole… - Scientific Reports, 2024 - nature.com
Since their invention, tissue expanders, which are designed to trigger additional skin growth,
have revolutionised many reconstructive surgeries. Currently, however, the sole quantitative …

A mesh-free approach to incorporate complex anisotropic and heterogeneous material properties into eye-specific finite element models

R Grytz, K Krishnan, R Whitley, V Libertiaux… - Computer methods in …, 2020 - Elsevier
Commercial finite element modeling packages do not have the tools necessary to effectively
incorporate the complex anisotropic and heterogeneous material properties typical of the …

Modeling the biomechanics of the conventional aqueous outflow pathway microstructure in the human eye

A Karimi, R Razaghi, SM Rahmati, JC Downs… - Computer methods and …, 2022 - Elsevier
Background and objective Intraocular pressure (IOP) is determined by aqueous humor
outflow resistance, which is a function of the combined resistance of Schlemm's canal (SC) …