Safe, therapeutically effective, and patient-compliant drug delivery systems are needed to
design novel tools and strategies to combat the deadliest of diseases such as cancer, SARS …

Gene therapy is the process of introducing foreign genomic materials into host cells to elicit
a therapeutic benefit. Although initially the main focus of gene therapy was on special …

Gene transfer methods are promising in the field of gene therapy. Current methods for gene
transfer include three major groups: viral, physical and chemical methods. This review …

The majority of currently available drugs and tool compounds exhibit an inhibitory
mechanism of action and there is a relative lack of pharmaceutical agents that are capable …

Previously, several individuals with X-linked SCID (SCID-X1) were treated by gene therapy
to restore the missing IL-2 receptor γ (IL2RG) gene to CD34+ BM precursor cells using …

Achieving the full potential of zinc-finger nucleases (ZFNs) for genome engineering in
human cells requires their efficient delivery to the relevant cell types. Here we exploited the …

In the late 1970s, it was predicted that gene therapy would be applied to humans within a
decade. However, despite some success, gene therapy has still not become a routine …

Meganucleases are sequence-specific endonucleases recognizing large (> 12 bp)
sequence sites and several laboratories have used these proteins to induce highly efficient …

The widespread clinical implementation of gene therapy requires the ability to stably
integrate genetic information through gene transfer vectors in a safe, effective, and …

Periodontitis is a chronic disease that begins with a period of inflammation of the supporting
tissues of the teeth table and then progresses, destroying the tissues until loss of the teeth …