Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases

L Wang, J Li, L Di - Medicinal Research Reviews, 2022 - Wiley Online Library
Abstract Glycogen synthase kinase‐3 (GSK3) is a highly evolutionarily conserved
serine/threonine protein kinase first identified as an enzyme that regulates glycogen …

Repurposing existing drugs for the treatment of COVID-19/SARS-CoV-2 infection: A review describing drug mechanisms of action

H Yousefi, L Mashouri, SC Okpechi, N Alahari… - Biochemical …, 2021 - Elsevier
The outbreak of a novel coronavirus (SARS-CoV-2) has caused a major public health
concern across the globe. SARS-CoV-2 is the seventh coronavirus that is known to cause …

[HTML][HTML] Glycogen synthase kinase-3 (GSK-3)-targeted therapy and imaging

MK Pandey, TR DeGrado - Theranostics, 2016 - ncbi.nlm.nih.gov
Abstract Glycogen synthase kinase-3 (GSK-3) is associated with various key biological
processes, including glucose regulation, apoptosis, protein synthesis, cell signaling, cellular …

[HTML][HTML] Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors

N Moussa, N Dayoub - Saudi Pharmaceutical Journal, 2023 - Elsevier
This review highlights the potential role of cyclooxygenase-2 enzyme (COX-2) in the
pathogenesis of Alzheimer's disease (AD) and the potential therapeutic use of non-steroidal …

Therapeutic molecules against type 2 diabetes: What we have and what are we expecting?

A Kumar, SK Bharti, A Kumar - Pharmacological Reports, 2017 - Elsevier
Abstract World Health Organization (WHO) has identified diabetes as one of the fastest
growing non-communicable diseases with 422 million patients around the world in 2014 …

Drug repurposing in dentistry: Towards application of small molecules in dentin repair

AA Birjandi, FR Suzano, PT Sharpe - International Journal of Molecular …, 2020 - mdpi.com
One of the main goals of dentistry is the natural preservation of the tooth structure following
damage. This is particularly implicated in deep dental cavities affecting dentin and pulp …

Cromolyn chitosan nanoparticles as a novel protective approach for colorectal cancer

TK Motawi, SA El-Maraghy, AN ElMeshad… - Chemico-Biological …, 2017 - Elsevier
Colorectal cancer is the third most common cancer in the world. Cromolyn is a mast cell
stabilizer and was proposed as an anticancer agent; however its high polarity limits its …

Chronic over-nutrition and dysregulation of GSK3 in diseases

X Liu, Z Yao - Nutrition & metabolism, 2016 - Springer
Loss of cellular response to hormonal regulation in maintaining metabolic homeostasis is
common in the process of aging. Chronic over-nutrition may render cells insensitive to such …

Revisiting the role of GSK3, a modulator of innate immunity, in idiopathic inclusion body myositis

M Piazzi, A Bavelloni, V Cenni, I Faenza, WL Blalock - Cells, 2021 - mdpi.com
Idiopathic or sporadic inclusion body myositis (IBM) is the leading age-related (onset> 50
years of age) autoimmune muscular pathology, resulting in significant debilitation in affected …

Potential effects of nonsteroidal anti-inflammatory drugs in the prevention and treatment of type 2 diabetes mellitus

PN Bellucci, MF González Bagnes… - Journal of …, 2017 - journals.sagepub.com
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a group of heterogeneous drugs largely
known for their anti-inflammatory, antipyretic, and analgesic effects, which are met by means …