Viruses encode for structural proteins that participate in virion formation and include capsid
and envelope proteins. In addition, viruses encode for an array of non-structural accessory …

Abstract The 1.75-Å crystal structure of the uracil-DNA glycosylase from herpes simplex virus
type-1 reveals a new fold, distantly related to dinucleotide-binding proteins. Complexes with …

Publisher Summary Uracil residues are introduced into prokaryotic and eukaryotic
deoxyribonucleic acid (DNA) as a normal physiological process during DNA synthesis, and …

Using a transient replication assay in which cosmid DNAs were cotransfected into Vero
cells, we had previously demonstrated that oriLyt replication required six Epstein-Barr virus …

The role of the accessory gene product Vpr during human immunodeficiency virus type 1
infection remains unclear. We have used the yeast two-hybrid system to identify cellular …

Uracil-DNA glycosylase releases free uracil from DNA and initiates base excision repair for
removal of this potentially mutagenic DNA lesion. Using the yeast two-hybrid system, human …

Herpes simplex virus (HSV) encodes a uracil DNA glycosylase (UNG; UL2), which has been
shown to be dispensable for normal replication of HSV-1 in cultured cells (J. Mullaney, HW …

HIV-1 reverse transcriptase discriminates poorly between dUTP and dTTP, and accordingly,
viral DNA products become heavily uracilated when viruses infect host cells that contain …

We report that a major subpopulation of monocyte-derived macrophages (MDMs) contains
high levels of dUTP, which is incorporated into HIV-1 DNA during reverse transcription (U/A …

The African swine fever virus (ASFV) gene E165R, which is homologous to dUTPases, has
been characterized. A multiple alignment of dUTPases showed the conservation in ASFV …