Multidrug resistance (MDR) poses a significant obstacle to effective cancer treatment, and
the tumor microenvironment (TME) is crucial for MDR development and reversal. The TME …

Nanovaccines have gathered significant attention for their potential to elicit tumor-specific
immunological responses. Despite notable progress in tumor immunotherapy, nanovaccines …

Adjuvants play an important role in enhancing vaccine‐induced immune protection.
Adequate cellular uptake, robust lysosomal escape, and subsequent antigen cross …

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon (STING) pathway is a key
mediator of innate immunity involved in cancer development and treatment. The roles of …

Cancer nanovaccine is a promising therapeutic strategy; however, the complicated
composition and ambiguous structure of cancer nanovaccines hinder their clinical …

The tumor microenvironment typically possesses immunosuppressive properties that hinder
the effectiveness of antitumor immune responses, even in the context of immunotherapies …

Protein or peptide cancer vaccines usually include immune potentiators, so-called
adjuvants. However, it remains challenging to identify structurally simple, chemically …

Cyclic dinucleotides (CDNs) are natural agonists of the stimulator of interferon genes
(STING), which is an attractive immunotherapy target. Currently, CDNs and their derivatives …

Systemic lupus erythematosus (SLE) is an autoimmune disease in which autoreactive CD4+
T cells play an essential role. We extracted CD4+ T cells from SLE-prone Fcgr2b-/-mice to …

The stimulator of interferon genes (STING) pathway is a potent therapeutic target for innate
immunity. Despite the efforts to develop pocket‐dependent small‐molecule STING agonists …