The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …

Activation of the mineralocorticoid receptor (MR) in the distal nephron by its ligand,
aldosterone, plays an important role in sodium reabsorption and blood pressure regulation …

The mineralocorticoid receptor (MR) was originally identified as a regulator of blood
pressure, able to modulate renal sodium handling in response to its principal ligand …

Myocardial injury, mechanical stress, neurohormonal activation, inflammation, and/or aging
all lead to cardiac remodeling, which is responsible for cardiac dysfunction and …

The renin angiotensin aldosterone system is a key regulator of blood pressure. Aldosterone
is the final effector of this pathway, acting predominantly via mineralocorticoid receptors …

Aldosterone contributes to end-organ damage in heart failure and chronic kidney disease.
Mineralocorticoid-receptor inhibitors limit activation of the receptor by aldosterone and slow …

Aldosterone is the most known mineralocorticoid hormone synthesized by the adrenal
cortex. The genomic pathway displayed by aldosterone is attributed to the mineralocorticoid …

Mineralocorticoid receptor (MR), a hormone-activated transcription factor belonging to the
nuclear receptor superfamily, exerts widespread actions in many tissues such as tight …

This editorial refers to 'Diverging effects of enalapril or eplerenone in primary prevention
against doxorubicininduced cardiotoxicity'by R. Hullin et al., pp. 272–281 and 'Inhibition of …

Vascular calcification is frequently found already in early stages of chronic kidney disease
(CKD) patients and is associated with high cardiovascular risk. The process of vascular …