The voltage-gated KCNQ1 (KvLQT1, Kv7. 1) potassium channel plays a crucial role in
shaping the cardiac action potential as well as in controlling the water and salt homeostasis …

Voltage-gated potassium (Kv) channels mediate rapid, selective diffusion of K+ ions through
the plasma membrane, controlling cell excitability, secretion and signal transduction. KCNE …

KCNQ1, also known as Kv7. 1, is a voltage-dependent K+ channel that regulates gastric
acid secretion, salt and glucose homeostasis, and heart rhythm. Its functional properties are …

Atrial fibrillation (AF) is a common cardiac arrhythmia whose molecular etiology is poorly
understood. We studied a family with hereditary persistent AF and identified the causative …

The bacterium Deinococcus radiodurans survives ionizing irradiation and other DNA-
damaging assaults at doses that are lethal to all other organisms. How D. radiodurans …

TBX3 is critical for human development: mutations in TBX3 cause congenital anomalies in
patients with ulnar-mammary syndrome. Data from mice and humans suggest multiple roles …

Arrhythmias originating in scarred ventricular myocardium are a major cause of death, but
the underlying mechanism allowing these rhythms to exist remains unknown. This gap in …

Voltage-gated potassium (KV) channels are modulated by at least three distinct classes of
proteins including the KCNE family of single transmembrane accessory subunits. In the …

OBJECTIVES: This study was designed to determine whether ionic currents in right
ventricular myocytes from explanted human transplant recipient hearts are related to right …

In an attempt to compensate for compromised hemodynamics in heart failure, neurohumoral
mechanisms are activated that trigger fundamental changes in gene expression and in …