Functions of interoception: From energy regulation to experience of the self

KS Quigley, S Kanoski, WM Grill, LF Barrett… - Trends in …, 2021 - cell.com
We review recent work on the functions of interoceptive processing, by which the nervous
system anticipates, senses, and integrates signals originating from the body. We focus on …

Assessing neurogenic lower urinary tract dysfunction after spinal cord injury: Animal models in preclinical neuro-urology research

AW Doelman, F Streijger, SJA Majerus, MS Damaser… - Biomedicines, 2023 - mdpi.com
Neurogenic bladder dysfunction is a condition that affects both bladder storage and voiding
function and remains one of the leading causes of morbidity after spinal cord injury (SCI) …

The NLRP3 inflammasome mediates inflammation produced by bladder outlet obstruction

FM Hughes Jr, HM Hill, CM Wood, AT Edmondson… - The Journal of …, 2016 - Elsevier
Purpose While bladder outlet obstruction is well established to elicit an inflammatory
reaction in the bladder that leads to overactive bladder and fibrosis, little is known about the …

[HTML][HTML] Intravesical activation of the cation channel TRPV4 improves bladder function in a rat model for detrusor underactivity

Y Deruyver, E Weyne, K Dewulf, R Rietjens, S Pinto… - European Urology, 2018 - Elsevier
Background Improvement of bladder emptying by modulating afferent nerve activity is an
attractive therapeutic strategy for detrusor underactivity. Transient receptor potential vanilloid …

Benefits and limitations of animal models in partial bladder outlet obstruction for translational research

T Kitta, Y Kanno, H Chiba, M Higuchi… - … Journal of Urology, 2018 - Wiley Online Library
The functions of the lower urinary tract have been investigated for more than a century.
Lower urinary tract symptoms, such as incomplete bladder emptying, weak urine stream …

From the rodent spinal cord injury model to human application: promises and challenges

V Dietz, ME Schwab - Journal of neurotrauma, 2017 - liebertpub.com
Repair of the spinal cord and improvement of mobility after injury has been a matter of basic
and clinical research for several decades. A number of repair approaches were performed in …

Anti-Nogo-A antibodies as a potential causal therapy for lower urinary tract dysfunction after spinal cord injury

MP Schneider, AM Sartori, BV Ineichen… - Journal of …, 2019 - Soc Neuroscience
Loss of bladder control is common after spinal cord injury (SCI) and no causal therapies are
available. Here we investigated whether function-blocking antibodies against the nerve-fiber …

Early sacral neuromodulation ameliorates urinary bladder function and structure in complete spinal cord injury minipigs

EE Keller, I Patras, I Hutu, K Roider… - Neurourology and …, 2020 - Wiley Online Library
Aims To determine the effects of early sacral neuromodulation (SNM) and pudendal
neuromodulation (PNM) on lower urinary tract (LUT) function, minipigs with complete spinal …

Molecular mechanism operating in animal models of neurogenic detrusor overactivity: A systematic review focusing on bladder dysfunction of neurogenic origin

A Ferreira, D Nascimento, CD Cruz - International Journal of Molecular …, 2023 - mdpi.com
Neurogenic detrusor overactivity (NDO) is a severe lower urinary tract disorder,
characterized by urinary urgency, retention, and incontinence, as a result of a neurologic …

[HTML][HTML] The NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome mediates inflammation and voiding dysfunction in a lipopolysaccharide …

FM Hughes Jr, JG Kennis, MN Youssef… - Journal of clinical & …, 2016 - ncbi.nlm.nih.gov
Objective NOD-like receptors (NLRs) sense sterile and non-sterile signals and form
inflammasomes which trigger an inflammatory response through the activation of caspase-1 …