7α-Hydroxysteroid dehydrogenase (7α-HSDH; 1 EC 1.1. 1.159) is an NAD+-dependent
oxidoreductase belonging to the short-chain dehydrogenase/reductase (SDR) 1 family. It …

The alcohol dehydrogenases (ADH) and their genes (Adh) of Drosophila have been much
studied by population and evolutionary biologists. I attempt to put some of these studies into …

Publisher Summary This chapter elaborates the role of 17β-hydroxysteroid dehydroenases
(17HSD) in the regulation of estrogen action. Proper and relevant steroid hormone influence …

Drosophila alcohol dehydrogenase (DADH) is an NAD+-dependent enzyme that catalyzes
the oxidation of alcohols to aldehydes/ketones. DADH is the member of the short-chain …

Drosophila alcohol dehydrogenase (DADH; EC 1.1. 1.1) is a NAD (H)-dependent
oxidoreductase belonging to the short-chain dehydrogenases/reductases (SDR) family. This …

Abstract Human 17β-hydroxysteroid dehydrogenase (17-HSD) type 1 predominantly
catalyzes the 17β-reduction of estrone to estradiol. The present results, however, show that …

Abstract Human 17β-hydroxysteroid dehydrogenase (17-HSD) type 1 catalyzes the
conversion of the low activity estrogen, estrone, into highly active estradiol, both in the …

Carboxylate reductases (CARs, EC 1.2. 1.30) generate aldehydes from their corresponding
carboxylic acid with high selectivity. Little is known about the structure of CARs and their …

Presenilins are the catalytic components of γ-secretase, an intramembrane-cleaving
protease whose substrates include β-amyloid precursor protein (βAPP) and the Notch …

GDP-4-keto-6-deoxy-d-mannose epimerase/reductase is a bifunctional enzyme responsible
for the last step in the biosynthesis of GDP-l-fucose, the substrate of fucosyl transferases …