A growing body of evidence has emerged demonstrating a pathological link between
oxidative stress and schizophrenia. This evidence identifies oxidative stress as a …

Dopamine is an inhibitory neurotransmitter involved in the pathology of schizophrenia. The
revised dopamine hypothesis states that dopamine abnormalities in the mesolimbic and …

Administration of noncompetitive NMDA/glutamate receptor antagonists, such as
phencyclidine (PCP) and ketamine, to humans induces a broad range of schizophrenic-like …

The classical dopamine hypothesis of schizophrenia postulates a hyperactivity of
dopaminergic transmission at the D2 receptor. We measured in vivo occupancy of striatal D2 …

Background: Abnormalities of dopamine function in schizophrenia are suggested by the
common antidopaminergic properties of antipsychotic medications. However, direct …

From Aaron T. Beck and colleagues, this is the definitive work on the cognitive model of
schizophrenia and its treatment. The volume integrates cognitive-behavioral and biological …

This pioneering work sets forth an integrative model for understanding the development of
psychopathology. What makes a person vulnerable to mental illness in general? To specific …

Spontaneous low-frequency fluctuations in the blood oxygen level–dependent (BOLD)
functional magnetic resonance imaging (MRI) signal have been shown to reflect neural …

Adolescence is characterized by increased risk-taking, novelty-seeking, and locomotor
activity, all of which suggest a heightened appetitive drive. The neurotransmitter dopamine is …

Prenatal exposure to infection is associated with increased liability to schizophrenia, and it is
believed that such an association is mediated by the maternal immune response, in …