Cognitive and motor performance measures are commonly employed in multiple sclerosis
(MS) research, particularly when the purpose is to determine the efficacy of treatment. The …

In patients with multiple sclerosis (MS), grey matter damage is widespread and might
underlie many of the clinical symptoms, especially cognitive impairment. This relation …

Multiple sclerosis (MS) is a progressive disease of the CNS that is characterised by
widespread lesions in the brain and spinal cord. MS results in motor, cognitive, and …

Abstract See Chard and Miller (doi: 10.1093/brain/awv354) for a scientific commentary on
this article. Grey matter atrophy is common in multiple sclerosis. However, in contrast with …

Patients with the main clinical phenotypes of multiple sclerosis (MS) manifest varying
degrees of brain atrophy beyond that of normal aging. Assessment of atrophy helps to …

Due to the heterogeneous nature of the disease, it is a challenge to capture disease activity
of multiple sclerosis (MS) in a reliable and valid way. Therefore, it can be difficult to assess …

Clinically significant depression can affect up to 50% of patients with multiple sclerosis over
the course of their lifetime. It is associated with an increased morbidity and mortality and is …

Cognitive impairment occurs in roughly 50% of patients with multiple sclerosis (MS). It is well
known that processing speed and episodic memory deficits are the most common …

The paired thalamic nuclei are gray matter (GM) structures on both sides of the third ventricle
that play major roles in cortical activation, relaying sensory information to the higher cortical …

Cognitive impairment is common in multiple sclerosis (MS), especially when assessed by
neuropsychological tests that emphasize mental processing speed, episodic memory, and …