State of the science on mild cognitive impairment (MCI)
ND Anderson - CNS spectrums, 2019 - cambridge.org
Mild cognitive impairment (MCI) represents a transitional stage between healthy aging and
dementia, and affects 10–15% of the population over the age of 65. The failure of drug trials …
dementia, and affects 10–15% of the population over the age of 65. The failure of drug trials …
Alzheimer's disease: from firing instability to homeostasis network collapse
S Frere, I Slutsky - Neuron, 2018 - cell.com
Alzheimer's disease (AD) starts from pure cognitive impairments and gradually progresses
into degeneration of specific brain circuits. Although numerous factors initiating AD have …
into degeneration of specific brain circuits. Although numerous factors initiating AD have …
[HTML][HTML] The aging astrocyte transcriptome from multiple regions of the mouse brain
Aging brains undergo cognitive decline, associated with decreased neuronal synapse
number and function and altered metabolism. Astrocytes regulate neuronal synapse …
number and function and altered metabolism. Astrocytes regulate neuronal synapse …
[HTML][HTML] Arizona study of aging and neurodegenerative disorders and brain and body donation program
Abstract The Brain and Body Donation Program (BBDP) at Banner Sun Health Research
Institute (http://www. brainandbodydonationprogram. org) started in 1987 with brain-only …
Institute (http://www. brainandbodydonationprogram. org) started in 1987 with brain-only …
Locus coeruleus cellular and molecular pathology during the progression of Alzheimer's disease
SC Kelly, B He, SE Perez, SD Ginsberg… - Acta neuropathologica …, 2017 - Springer
A major feature of Alzheimer's disease (AD) is the loss of noradrenergic locus coeruleus
(LC) projection neurons that mediate attention, memory, and arousal. However, the extent to …
(LC) projection neurons that mediate attention, memory, and arousal. However, the extent to …
[HTML][HTML] Response of the medial temporal lobe network in amnestic mild cognitive impairment to therapeutic intervention assessed by fMRI and memory task …
Studies of individuals with amnestic mild cognitive impairment (aMCI) have detected
hyperactivity in the hippocampus during task-related functional magnetic resonance imaging …
hyperactivity in the hippocampus during task-related functional magnetic resonance imaging …
Golgi fragmentation–One of the earliest organelle phenotypes in Alzheimer's disease neurons
H Haukedal, GI Corsi, VP Gadekar… - Frontiers in …, 2023 - frontiersin.org
Alzheimer's disease (AD) is the most common cause of dementia, with no current cure.
Consequently, alternative approaches focusing on early pathological events in specific …
Consequently, alternative approaches focusing on early pathological events in specific …
Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies
Y Chen, AKY Fu, NY Ip - Pharmacology & therapeutics, 2019 - Elsevier
Abstract Alzheimer's disease (AD), the most prevalent neurodegenerative disease in the
elderly population, is characterized by progressive cognitive decline and pathological …
elderly population, is characterized by progressive cognitive decline and pathological …
Hippocampal plasticity during the progression of Alzheimer's disease
Neuroplasticity involves molecular and structural changes in central nervous system (CNS)
throughout life. The concept of neural organization allows for remodeling as a compensatory …
throughout life. The concept of neural organization allows for remodeling as a compensatory …
Functional excitatory to inhibitory synaptic imbalance and loss of cognitive performance in people with Alzheimer's disease neuropathologic change
Individuals at distinct stages of Alzheimer's disease (AD) show abnormal
electroencephalographic activity, which has been linked to network hyperexcitability and …
electroencephalographic activity, which has been linked to network hyperexcitability and …