Behavioral and neurobiological mechanisms of pavlovian and instrumental extinction learning
This article reviews the behavioral neuroscience of extinction, the phenomenon in which a
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
behavior that has been acquired through Pavlovian or instrumental (operant) learning …
Animal models of drug relapse and craving: from drug priming-induced reinstatement to incubation of craving after voluntary abstinence
High rates of relapse to drug use during abstinence is a defining feature of drug addiction. In
abstinent drug users, drug relapse is often precipitated by acute exposure to the self …
abstinent drug users, drug relapse is often precipitated by acute exposure to the self …
A molecular mechanism for choosing alcohol over an alternative reward
Alcohol addiction leads to increased choice of alcohol over healthy rewards. We established
an exclusive choice procedure in which~ 15% of outbred rats chose alcohol over a high …
an exclusive choice procedure in which~ 15% of outbred rats chose alcohol over a high …
Circuit and synaptic plasticity mechanisms of drug relapse
High rates of relapse to drug use during abstinence is a defining feature of human drug
addiction. This clinical scenario has been studied at the preclinical level using different …
addiction. This clinical scenario has been studied at the preclinical level using different …
The anterior insular cortex→ central amygdala glutamatergic pathway is critical to relapse after contingency management
Despite decades of research on neurobiological mechanisms of psychostimulant addiction,
the only effective treatment for many addicts is contingency management, a behavioral …
the only effective treatment for many addicts is contingency management, a behavioral …
Role of dorsomedial striatum neuronal ensembles in incubation of methamphetamine craving after voluntary abstinence
D Caprioli, M Venniro, M Zhang… - Journal of …, 2017 - Soc Neuroscience
We recently developed a rat model of incubation of methamphetamine craving after choice-
based voluntary abstinence. Here, we studied the role of dorsolateral striatum (DLS) and …
based voluntary abstinence. Here, we studied the role of dorsolateral striatum (DLS) and …
Distinct Fos-expressing neuronal ensembles in the ventromedial prefrontal cortex mediate food reward and extinction memories
In operant learning, initial reward-associated memories are thought to be distinct from
subsequent extinction-associated memories. Memories formed during operant learning are …
subsequent extinction-associated memories. Memories formed during operant learning are …
Incubation of methamphetamine craving is associated with selective increases in expression of Bdnf and trkb, glutamate receptors, and epigenetic enzymes in cue …
Cue-induced methamphetamine seeking progressively increases after withdrawal
(incubation of methamphetamine craving), but the underlying mechanisms are largely …
(incubation of methamphetamine craving), but the underlying mechanisms are largely …
Nucleus accumbens Drd1-expressing neurons control aggression self-administration and aggression seeking in mice
We recently developed a mouse model of appetitive operant aggression and reported that
adult male outbred CD-1 mice lever-press for the opportunity to attack subordinate male …
adult male outbred CD-1 mice lever-press for the opportunity to attack subordinate male …
Neural circuit dynamics of drug-context associative learning in the mouse hippocampus
Y Sun, LM Giocomo - Nature Communications, 2022 - nature.com
The environmental context associated with previous drug consumption is a potent trigger for
drug relapse. However, the mechanism by which neural representations of context are …
drug relapse. However, the mechanism by which neural representations of context are …