Background Fluorescence-guided surgery (FGS) is a technique used to enhance
visualization of tumor margins in order to increase the extent of tumor resection in glioma …

Objective Fluorescence guidance has a demonstrated potential in maximizing the extent of
high-grade glioma resection. Different fluorophores (fluorescent biomarkers), including 5 …

Biomedical optics is a broadly interdisciplinary field at the interface of optical engineering,
biophysics, computer science, medicine, biology, and chemistry, helping us understand light …

Biomarkers are indicators of biological processes and hold promise for the diagnosis and
treatment of disease. Gliomas represent a heterogeneous group of brain tumors with marked …

Fluorescence imaging in neurosurgery has a long historical development, with various
biomarkers and biochemical agents being used, and numerous technological approaches …

Fluorescence lifetime imaging (FLIm) is an optical spectroscopic imaging technique capable
of real‐time assessments of tissue properties in clinical settings. Label‐free FLIm is sensitive …

Current clinical brain imaging techniques used for surgical planning of tumor resection lack
intraoperative and real‐time feedback; hence surgeons ultimately rely on subjective …

This study evaluates the potential of time-resolved laser induced fluorescence spectroscopy
(TR-LIFS) as intra-operative tool for the delineation of brain tumor from normal brain. Forty …

The goal of this study is to determine the potential of time-resolved laser-induced
fluorescence spectroscopy (TR-LIFS) as an adjunctive tool for delineation of brain tumor …

Advanced stage glioma is the most aggressive form of malignant brain tumors with a short
survival time. Real-time pathology assisted, or image guided surgical procedures that …