Cellular membranes function as permeability barriers that separate cells from the external
environment or partition cells into distinct compartments. These membranes are lipid …

The physiological heterogeneity of platelets leads to diverse responses and the formation of
discrete subpopulations upon platelet stimulation. Procoagulant platelets are an example of …

Glycerophospholipids are synthesized primarily in the cytosolic leaflet of the endoplasmic
reticulum (ER) membrane and must be equilibrated between bilayer leaflets to allow the ER …

The host proteins SERINC3 and SERINC5 are HIV-1 restriction factors that reduce infectivity
when incorporated into the viral envelope. The HIV-1 accessory protein Nef abrogates …

The TMEM16 family of membrane proteins displays a remarkable functional dichotomy–
while some family members function as Ca 2+-activated anion channels, the majority of …

The negatively charged aminophospholipid, phosphatidylserine (PtdSer), is located in the
inner leaflet of the plasma membrane in normal cells, and may be exposed to the outer …

TMEM16F, a member of the conserved TMEM16 family, plays a central role in the initiation
of blood coagulation and the fusion of trophoblasts. The protein mediates passive ion and …

The calcium-activated chloride channel (CaCC) TMEM16A plays crucial roles in regulating
neuronal excitability, smooth muscle contraction, fluid secretion and gut motility. While …

The calcium-activated TMEM16 proteins and the mechanosensitive/osmolarity-activated
OSCA/TMEM63 proteins belong to the Transmembrane Channel/Scramblase (TCS) …

Abstract Transmembrane protein 16 F (TMEM16F) is a Ca2+-activated homodimer which
functions as an ion channel and a phospholipid scramblase. Despite the availability of …