Selenization of Small Molecule Drugs: A New Player on the Board
There is an urgent need to develop safer and more effective modalities for the treatment of a
wide range of pathologies due to the increasing rates of drug resistance, undesired side …
wide range of pathologies due to the increasing rates of drug resistance, undesired side …
Ni (II) mixed-ligand chelates based on 2-hydroxy-1-naphthaldehyde as antimicrobial agents: Synthesis, characterization, and molecular modeling
M Ismael, AMM Abdel-Mawgoud, MK Rabia… - Journal of Molecular …, 2021 - Elsevier
New Ni (II) ternary chelates; based on 2-hydroxy-1-naphthaldehyde Schiff-base ligand with
various N-heterocyclic co-ligands, were synthesized and characterized. Structural analysis …
various N-heterocyclic co-ligands, were synthesized and characterized. Structural analysis …
From Synergy to Monotherapy: Discovery of Novel 2,4,6-Trisubstituted Triazine Hydrazone Derivatives with Potent Antifungal Potency In Vitro and In Vivo
F Xie, Y Hao, Y Liu, J Bao, R Wang, X Chi… - Journal of Medicinal …, 2024 - ACS Publications
Invasive fungal infections pose a serious threat to public health and are associated with high
mortality and incidence rates. The development of novel antifungal agents is urgently …
mortality and incidence rates. The development of novel antifungal agents is urgently …
In vivo active organometallic-containing antimycotic agents
R Rubbiani, T Weil, N Tocci, L Mastrobuoni… - RSC Chemical …, 2021 - pubs.rsc.org
Fungal infections represent a global problem, notably for immunocompromised patients in
hospital, COVID-19 patient wards and care home settings, and the ever-increasing …
hospital, COVID-19 patient wards and care home settings, and the ever-increasing …
Copper Acts Synergistically With Fluconazole in Candida glabrata by Compromising Drug Efflux, Sterol Metabolism, and Zinc Homeostasis
A Gaspar-Cordeiro, C Amaral, V Pobre… - Frontiers in …, 2022 - frontiersin.org
The synergistic combinations of drugs are promising strategies to boost the effectiveness of
current antifungals and thus prevent the emergence of resistance. In this work, we show that …
current antifungals and thus prevent the emergence of resistance. In this work, we show that …
Design, synthesis and biological evaluation of a series of iron and copper chelating deferiprone derivatives as new agents active against Candida albicans
M Bortolami, F Pandolfi, A Messore, D Rocco… - Bioorganic & Medicinal …, 2021 - Elsevier
Candida albicans, in specific conditions, is responsible of severe invasive systemic
candidiasis that are related to its ability to produce biofilm on biological and artificial …
candidiasis that are related to its ability to produce biofilm on biological and artificial …
A copper(II)-binding triazole derivative with ionophore properties is active against Candida spp.
A Gaspar-Cordeiro, S da Silva, M Aguiar… - JBIC Journal of …, 2020 - Springer
Invasive fungal infections (IFIs) are life threatening and existing antifungal drugs are not
completely effective due to undesirable side effects and resistance emergence. Azoles are …
completely effective due to undesirable side effects and resistance emergence. Azoles are …
A brief review of fluconazole as an antifungal agent and the need for research into its nanoformulation
S Nagaraj - Journal of Achievements in Materials and …, 2022 - journalamme.org
Antifungals compounds have gained significant attention, and in this context, fluconazole as
an antifungal is used predominantly, and the use of a nanoformulated form of this is …
an antifungal is used predominantly, and the use of a nanoformulated form of this is …